{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T02:55:55Z","timestamp":1776567355187,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002635","name":"Inha University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Glucosamine (GlcN) is generally used as a dietary supplement because of its antiinflammatory effects. We evaluated the antiallergic effect of GlcN in mice with allergic asthma and rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two mice were allocated equally into 4 groups (n = 8). In group A (control), we performed intraperitoneal\/intranasal challenge using sterile saline. In group B (asthma\/rhinitis), we used ovalbumin for intraperitoneal\/intranasal challenge to induce allergic asthma and rhinitis. In groups C and D (GlcN treatment), mice were given 1% and 5% GlcN throughout the period of ovalbumin challenge, respectively. We measured serum total and ovalbumin\u2010specific immunoglobulin E (IgE), cytokine titers (interleukin\u20101, \u20104, \u20105, \u20106, \u201010, and \u201017; tumor necrosis factor\u2010\u03b1; and interferon\u2010\u03b3), and the number of inflammatory cells (eosinophils, neutrophils, lymphocytes) in bronchoalveolar lavage (BAL) fluid. We also performed histopathologic examination of the lung and nasal cavity. Finally, we performed real\u2010time polymerase chain reaction for the genes <jats:italic>Bcl\u20102<\/jats:italic>, <jats:italic>EC\u2010SOD<\/jats:italic>, <jats:italic>VEGF<\/jats:italic>, <jats:italic>caspase\u20103<\/jats:italic>, <jats:italic>Bax<\/jats:italic>, <jats:italic>COX\u20102<\/jats:italic>, <jats:italic>Hif\u20101\u03b1<\/jats:italic>, and <jats:italic>heme oxygenase\u20101<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with group B, group D had significant serum total and ovalbumin\u2010specific IgE decreases after GlcN treatment (<jats:italic>p<\/jats:italic> &lt; 0.05). Titers for IL\u20104, IL\u20105, IL\u20106, and IL\u201017 in BAL fluid were significantly decreased in group D (<jats:italic>p<\/jats:italic> &lt; 0.05). Eosinophils in BAL fluid were significantly decreased in group D compared with group B (<jats:italic>p<\/jats:italic> &lt; 0.05). Groups C and D showed significant improvement of inflammation compared with group B. Group D had significant downregulation of <jats:italic>EC\u2010SOD<\/jats:italic>, <jats:italic>Bax<\/jats:italic>, <jats:italic>Hif\u20101\u03b1<\/jats:italic>, and <jats:italic>heme oxygenase\u20101<\/jats:italic> compared with group B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GlcN had a significant antiallergic effect in mice with allergic asthma and rhinitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21967","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T20:32:38Z","timestamp":1496176358000},"page":"763-769","source":"Crossref","is-referenced-by-count":17,"title":["Glucosamine has an antiallergic effect in mice with allergic asthma and rhinitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Ah\u2010Yeoun","family":"Jung","sequence":"first","affiliation":[{"name":"WCSL of INtegrated Human Airway\u2010on\u2010a\u2010chip Department of Otorhinolaryngology, Inha University  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Jeong","family":"Heo","sequence":"additional","affiliation":[{"name":"WCSL of INtegrated Human Airway\u2010on\u2010a\u2010chip Department of Otorhinolaryngology, Inha University  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Hyo","family":"Kim","sequence":"additional","affiliation":[{"name":"WCSL of INtegrated Human Airway\u2010on\u2010a\u2010chip Department of Otorhinolaryngology, Inha University  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.737940"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.03.004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110638"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90962-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/12.4.43R"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01025.2008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.01.005"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12163"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02659.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02735.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2012.702841"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.6.3017"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2006.02.004"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2012.684800"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6123-6130.2001"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13031267"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4572"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3077"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/187221308786241929"},{"key":"e_1_2_5_21_1","first-page":"504","article-title":"[Expression of heme oxygenase\u20101 in nasal mucosa of allergic rhinitis guinea pig]","volume":"19","author":"Yu S","year":"2005","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000194692.51979.d1"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.12.004"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.494369"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02594.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048618"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939948"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2336"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2011.10.005"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.02.129"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i32.5381"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.12.027"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00139.x"},{"key":"e_1_2_5_34_1","first-page":"481","article-title":"Asthma exacerbation associated with glucosamine\u2010chondroitin supplement","volume":"15","author":"Tallia AF","year":"2002","journal-title":"J Am Board Fam Pract"}],"container-title":["International Forum of Allergy &amp; 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