{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:20:34Z","timestamp":1768818034782,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Pseudomonas aeruginosa<\/jats:italic> is a gram\u2010negative bacterium frequently implicated in recalcitrant sinonasal infections, especially in immunocompromised hosts. We report 6 cases of rapidly progressive pseudomonal acute rhinosinusitis producing tissue necrosis and, in certain cases, cranial nerve palsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of 6 patients with aggressive necrotizing sinonasal infections treated at 4 tertiary academic medical centers with sinonasal cultures growing <jats:italic>P. aeruginosa<\/jats:italic> in the absence of other pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6 patients were identified. In all cases, there was tissue necrosis that appeared to mimic an invasive process such as mucormycosis, prompting urgent surgical intervention. Pathologic analysis revealed fibropurulent exudates in backgrounds of positive <jats:italic>P. aeruginosa<\/jats:italic> cultures without evidence of invasive fungal organisms or malignancy. Four of the 6 patients presented with cranial nerve palsies, with 3 patients having vision changes and 3 complaining of trigeminal neuropathy. Four of 6 patients improved clinically over time after surgery and antibiotic therapy; 1 remains in follow\u2010up without complete improvement and 1 has succumbed to other causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>P. aeruginosa<\/jats:italic> is a tenacious organism that is frequently associated with severe, recalcitrant sinonasal infections. We report the first case series of necrotizing sinonasal infections caused by this organism, and illustrate that, in rare cases, <jats:italic>P. aeruginosa<\/jats:italic> may mimic and behave like life\u2010threatening conditions such as fulminant invasive fungal sinusitis or malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21981","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T10:48:35Z","timestamp":1500029315000},"page":"910-915","source":"Crossref","is-referenced-by-count":9,"title":["Aggressive necrotizing pseudomonal sinonasal infections"],"prefix":"10.1002","volume":"7","author":[{"given":"Edward C.","family":"Kuan","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery University of California  Los Angeles (UCLA) Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby A.","family":"Tajudeen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Rush University Medical Center  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Medical Center  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh K.","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Vanderbilt University Medical Center  Nashville TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben J.","family":"Glasgow","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California  Los Angeles (UCLA) Los Angeles CA"},{"name":"Department of Ophthalmology University of California  Los Angeles (UCLA) Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of California  Los Angeles (UCLA) Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"issue":"10","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1288\/00005537-198210000-00005","article-title":"Infectious facial and nasal cutaneous necrosis: evaluation and diagnosis","volume":"92","author":"Koopmann CF","year":"1982","journal-title":"Laryngoscope"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01386.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980301447-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300609"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131008900608"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamaoto.442a"},{"key":"e_1_2_6_8_1","first-page":"272","article-title":"Treatment of acute necrotizing fasciitis using negative pressure wound therapy and adjunctive NeutroPhase irrigation under the foam","volume":"25","author":"Crew JR","year":"2013","journal-title":"Wounds"},{"key":"e_1_2_6_9_1","first-page":"126","article-title":"NeutroPhase\u00ae in chronic non\u2010healing wounds","volume":"2","author":"Crew J","year":"2012","journal-title":"Int J Burns Trauma"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.93"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12889"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200212000-00016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000558"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T23:57:44Z","timestamp":1695945464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,14]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/alr.21981"],"URL":"https:\/\/doi.org\/10.1002\/alr.21981","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,14]]}}}