{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:11:55Z","timestamp":1782169915510,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is a commonly observed sequela after radiation therapy to the paranasal sinuses. The histopathologic features of radiation\u2010induced CRS have yet to be determined and may have major implications in disease management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A structured histopathology report was utilized to analyze sinus tissue removed during functional endoscopic sinus surgery (FESS). Histopathology variables, Lund\u2010Mackay score (LMS), and 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) scores were compared among patients with radiation\u2010induced CRS (CRSr), CRS without nasal polyps (CRSsNP), and CRS with nasal polyps (CRSwNP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen CRSr, 43 CRSsNP, and 56 CRSwNP patients who underwent FESS were analyzed. Compared with CRSsNP, CRSr cases had increased squamous metaplasia (40.0% vs 9.3%, <jats:italic>p<\/jats:italic> &lt; 0.013) and subepithelial edema (53.3% vs. 2.3%, <jats:italic>p<\/jats:italic> &lt; 0.001). Compared with CRSwNP, CRSr cases had fewer eosinophils per high\u2010power field (20.0% vs 50.0%, <jats:italic>p<\/jats:italic> &lt; 0.034), less basement membrane thickening (33.3% vs 76.8%, <jats:italic>p<\/jats:italic> &lt; 0.002), and fewer eosinophil aggregates (0.0% vs 30.4%, <jats:italic>p<\/jats:italic> &lt; 0.009). CRSr had significantly greater mean LMS (13.47 \u00b1 5.13 vs 7.07 \u00b1 4.79, <jats:italic>p<\/jats:italic> &lt; 0.001) compared with CRSsNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiation\u2010induced CRS patients exhibited greater squamous metaplasia and subepithelial edema when compared with a cohort of patients with CRSsNP, and decreased eosinophilia and basement membrane thickening compared with a cohort of CRSwNP patients. CRSr cases demonstrated no difference in eosinophilia or neutrophilia compared with CRSsNP, and decreased eosinophilia compared with CRSwNP, lending further credence to the unique nature of radiation in the development of CRS in this patient group. These findings may have major implications with regard to extent of surgical intervention and medical management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21989","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T06:14:40Z","timestamp":1500876880000},"page":"990-998","source":"Crossref","is-referenced-by-count":43,"title":["Distinct histopathologic features of radiation\u2010induced chronic sinusitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Hannah N.","family":"Kuhar","sequence":"first","affiliation":[{"name":"Rush Medical College Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby A.","family":"Tajudeen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Rush Sinus Program\u2010Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Heilingoetter","sequence":"additional","affiliation":[{"name":"Rush Medical College Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobeh","family":"Mahdavinia","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology Allergy\/Immunology Section\u2010Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gattuso","sequence":"additional","affiliation":[{"name":"Department of Pathology\u2010Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Ghai","sequence":"additional","affiliation":[{"name":"Department of Pathology\u2010Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferry","family":"Gunawan","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology Allergy\/Immunology Section\u2010Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidnag Z.","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology\u2010Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Tolekidis","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology\u2010Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete S.","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Rush Sinus Program\u2010Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.036"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.049"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25435"},{"key":"e_1_2_6_5_1","article-title":"Protective effects of a novel nutritional and phytonutrient blend on ultraviolet radiation\u2010induced skin damage and inflammatory response through aging defense mechanisms","author":"Wood SM","journal-title":"J Cosmet Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3004-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.07.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21032"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180325b6c"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410018106"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800510"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/08958370902767070"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.07.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4156"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.07.007"}],"container-title":["International Forum of Allergy &amp; 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