{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:53:32Z","timestamp":1780340012614,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The role of human papillomavirus (HPV) in sinonasal squamous cell carcinoma (SNSCC) is not well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Cancer Database was queried for cases of SNSCC with known HPV status. Demographics, socioeconomic variables, TNM stage, histology, grade, treatment modalities, and overall survival (OS) through 5 years were compared between HPV\u2010positive and HPV\u2010negative tumors. Cox proportional hazard regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven hundred seventy (770) cases were identified; 526 were HPV\u2010negative (68.3%) and 244 (31.7%) were HPV\u2010positive. Patients with HPV\u2010positive tumors were younger (58.0 vs 63.7 years, <jats:italic>p<\/jats:italic> &lt; 0.0001). Nasal cavity (49.4%) tumors were more likely to be HPV\u2010positive (<jats:italic>p<\/jats:italic> &lt; 0.05) than maxillary (18.8%), ethmoid (18.8%), and frontal (18.2%) sinus tumors. Large cell nonkeratinizing (42.4%), papillary (42.1%), and basaloid (56.5%) tumors were more likely than keratinizing (25.2%) tumors to be HPV\u2010positive (<jats:italic>p<\/jats:italic> &lt; 0.05). Well\u2010differentiated (grade I) tumors (9.0%) were less likely than higher grade tumors to be HPV\u2010positive (<jats:italic>p<\/jats:italic> &lt; 0.05). Gender, race, facility type, insurance type, median income, education level, Charlson\u2010Deyo comorbidity score, overall stage, T stage, N stage, M stage, tumor size, treatment modality, surgical approach, and surgical margins did not vary by HPV status (<jats:italic>p<\/jats:italic> \u2265 0.05). HPV\u2010positive tumors had higher OS than HPV\u2010negative tumors (<jats:italic>p<\/jats:italic> &lt; 0.0001). At 5 years, OS was 68.1% and 51.5% for HPV\u2010positive and HPV\u2010negative tumors, respectively. On multivariate analyses, HPV positivity remained a favorable prognostic factor (hazard ratio, 0.49; 95% confidence interval, 0.34\u20100.70).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HPV positivity is more common in nasal cavity SCC and nonkeratinizing SNSCC. It is also a favorable prognostic factor in SNSCC. Future studies on SNSCC should take HPV positivity into consideration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21996","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T16:46:36Z","timestamp":1504197996000},"page":"980-989","source":"Crossref","is-referenced-by-count":66,"title":["Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7903-2299","authenticated-orcid":false,"given":"Suat","family":"K\u0131l\u0131\u00e7","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rutgers New Jersey Medical School  Newark 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