{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T22:17:23Z","timestamp":1774909043201,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI072570"],"award-info":[{"award-number":["R01 AI072570"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 DC012067"],"award-info":[{"award-number":["K23 DC012067"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI104733"],"award-info":[{"award-number":["R01 AI104733"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL068546"],"award-info":[{"award-number":["R01 HL068546"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL078860"],"award-info":[{"award-number":["R01 HL078860"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) has a high propensity for recurrence. Studies suggest that eosinophilia influences disease severity and surgical outcomes, but the selection of sinonasal site for measuring eosinophilia has not been examined. The aim of this study was to investigate how region\u2010specific tissue eosinophilia affects radiographic severity, comorbidity prevalence, and polyp recurrence risk following sinus surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eosinophil cationic protein (ECP) levels in uncinate tissue (UT) and nasal polyp (NP) homogenates from 116 CRSwNP patients were measured using enzyme\u2010linked immunosorbent assay (ELISA). Clinical history, radiographic severity, and time to polyp recurrence were obtained from electronic health records. The correlations between baseline Lund\u2010Mackay scores and comorbidities were compared between UT and NP ECP levels. Cox regression and Kaplan\u2010Meier analysis were then performed to assess whether UT or NP ECP better predicted recurrence. Censoring occurred at 4 years or at last follow\u2010up if there was no endoscopic diagnosis of recurrent polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lund\u2010Mackay scores were significantly correlated with UT and NP ECP (<jats:italic>r<\/jats:italic> = 0.46 and 0.26 respectively, <jats:italic>p<\/jats:italic> &lt; 0.05). UT but not NP ECP was significantly higher in patients with asthma (<jats:italic>p<\/jats:italic> &lt; 0.01) and aspirin\u2010exacerbated respiratory disease (AERD) (<jats:italic>p<\/jats:italic> &lt; 0.05). Polyp recurrence risk was only significantly higher for patients with eosinophilic UT tissue (hazard ratio [HR] = 2.84, <jats:italic>p<\/jats:italic> = 0.025). When measured in NP, eosinophilia did not predict recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although ECP in NP was higher than in UT tissue, eosinophilia in UT tissue was a more clinically coherent biomarker of baseline radiographic severity, comorbid asthma and AERD, and prospective polyp recurrence risk than NP eosinophilia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22005","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T16:36:35Z","timestamp":1504283795000},"page":"1058-1064","source":"Crossref","is-referenced-by-count":25,"title":["A prospective analysis evaluating tissue biopsy location and its clinical relevance in chronic rhinosinusitis with nasal polyps"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0948-0624","authenticated-orcid":false,"given":"Ava R.","family":"Weibman","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia He","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whitney W.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Division of Allergy\u2010Immunology Department of Medicine Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia A.","family":"Suh","sequence":"additional","affiliation":[{"name":"Division of Allergy\u2010Immunology Department of Medicine Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline P.E.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alcina K.","family":"Lidder","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"},{"name":"University of Rochester School of Medicine and Dentistry University of Rochester Medical Center  Rochester NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Conley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Shintani\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju T.","family":"Peters","sequence":"additional","affiliation":[{"name":"Division of Allergy\u2010Immunology Department of Medicine Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie C.","family":"Grammer","sequence":"additional","affiliation":[{"name":"Division of Allergy\u2010Immunology Department of Medicine Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Allergy\u2010Immunology Department of Medicine Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Schleimer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"},{"name":"Division of Allergy\u2010Immunology Department of Medicine Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce K.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9]]},"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T01:15:39Z","timestamp":1696036539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/alr.22005"],"URL":"https:\/\/doi.org\/10.1002\/alr.22005","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}