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Several studies have pointed to the preventive and therapeutic potential of antioxidants in allergic disorders. However, little is known about the immunomodulatory effects of antioxidants in type I hypersensitivity. In this study we aimed to explore the impact of a water\u2010soluble antioxidant and \u03b1\u2010lipoic acid derivative, sodium zinc histidine dithiooctanamide (DHL\u2010HisZn), on mast\u2010cell\u2010 and T\u2010cell\u2010mediated allergic and immune responses both in vitro and in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The therapeutic impact of DHL\u2010HisZn on mast\u2010cell\u2010mediated type I hypersensitivity was evaluated by a mast\u2010cell degranulation assay using bone marrow\u2010derived mast cells and by a mouse model of ovalbumin (OVA)\u2010induced allergic rhinitis. The effect of DHL\u2010HisZn on the proportion of regulatory T cells (Tregs) was evaluated using flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the course of OVA\u2010induced allergic rhinitis in mice, serum nitrate was elevated, suggesting the involvement of oxidative stress in allergic responses. DHL\u2010HisZn not only suppressed mast\u2010cell degranulation but also ameliorated OVA\u2010induced nasal hypersensitivity, with significant suppression of serum nitrate. DHL\u2010HisZn treatment significantly suppressed OVA\u2010specific immunoglobulin E (IgE) but enhanced OVA\u2010specific IgG2a in OVA\u2010sensitized and nasal\u2010challenged mice. Furthermore, DHL\u2010HisZn treatment suppressed interleukin\u201017 production in OVA\u2010stimulated splenocytes. Finally, we demonstrated the induction of Tregs by DHL\u2010HisZn in concanavalin A blasts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that DHL\u2010HisZn may regulate mast\u2010cell\u2010, T\u2010helper 2 (Th2)\u2010, and Th17\u2010mediated allergic and immune responses by induction of Tregs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22008","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T16:32:38Z","timestamp":1504283558000},"page":"1095-1103","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic potential of \u03b1\u2010lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Toshiaki","family":"Nakano","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medical Sciences Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"Liver 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