{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:57:33Z","timestamp":1767650253084,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01 DC005805"],"award-info":[{"award-number":["R01 DC005805"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although the majority of patients with chronic rhinosinusitis without nasal polyposis (CRSsNP) suffer from bilateral disease, a subset suffer from unilateral disease. Currently, outcomes following endoscopic sinus surgery (ESS) for medically recalcitrant CRS are inferred from outcomes for patients with bilateral disease. This study compares outcomes of ESS between patients with unilateral and bilateral disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CRSsNP who failed appropriate medical therapy and elected ESS were enrolled between 2011 and 2015. Patients were dichotomized according to radiographic evidence of unilateral disease (Lund\u2010Mackay [LM] score = 0 for 1 side) or bilateral disease (LM \u2265 1 for both sides). The primary outcome of interest was the 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022), with secondary outcomes including the Brief Smell Identification Test (BSIT) and the Lund\u2010Kennedy (LK) endoscopy staging system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 190 patients met inclusion criteria consisting of 19 with unilateral (10%) and 171 with bilateral CRSsNP (90%). Both groups were similar across all preoperative demographic factors, SNOT\u201022, and BSIT scores. Postoperatively, patients with bilateral disease reported greater improvement in mean SNOT\u201022 scores compared to unilateral disease, but this difference was not statistically or clinically significant (\u221224.3 \u00b1 21.1 vs \u221221.5 \u00b1 24.0, <jats:italic>p<\/jats:italic> = 0.582). Mean LK scores improved for patients with bilateral disease but not unilateral disease, without a difference between groups (\u22122.0 \u00b1 3.5 vs \u22120.4 \u00b1 2.4, <jats:italic>p<\/jats:italic> = 0.090).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with unilateral CRSsNP experience improvement after ESS comparable to patients with bilateral disease on patient reported outcome measures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22020","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T13:52:44Z","timestamp":1506088364000},"page":"1162-1169","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of surgical outcomes between patients with unilateral and bilateral chronic rhinosinusitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Daniel M.","family":"Beswick","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health &amp; Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health &amp; Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naweed I.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Otolarynoglogy\u2013Head and Neck Surgery Vanderbilt University Medical Center  Nashville TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery, School of Medicine University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Stanford University  Stanford CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam S.","family":"DeConde","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology, School of Medicine University of California\u2013San Diego San Diego  CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-7083","authenticated-orcid":false,"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health &amp; Science University  Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3355"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21695_c"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000701"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701663417"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21526"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3482"},{"key":"e_1_2_6_8_1","first-page":"873","article-title":"Quality of life in patients with chronic rhinosinusitis and sleep dysfunction undergoing endoscopic sinus surgery: a pilot investigation of comorbid obstructive sleep apnea","volume":"141","author":"Alt JA","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21683"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21682"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.11.019"},{"issue":"23","key":"e_1_2_6_12_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1045"},{"volume-title":"The Brief Smell Identification Test Administration Manual","year":"2001","author":"Doty RL.","key":"e_1_2_6_17_1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199603000-00021"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21670"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_6_21_1","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21458"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21800"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.03.001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0175-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32834dfb3d"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21679"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2017.8.0195"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21350"}],"container-title":["International Forum of Allergy &amp; 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