{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:15:37Z","timestamp":1785575737185,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In this study we assessed patient outcomes after complete endoscopic sinus surgery (ESS) and aspirin desensitization for patients with aspirin\u2010exacerbated respiratory disease (AERD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was conducted for patients with aspirin challenge\u2013proven AERD who underwent complete ESS followed by aspirin desensitization. Outcomes assessed included need for revision surgery and quality\u2010of\u2010life measures using the 22\u2010item Sino\u2010Nasal Outcomes Test (SNOT\u201022). Data were collected preoperatively, postoperatively prior to desensitization, and then at intervals post\u2010desensitization through 30 months after aspirin desensitization. A longitudinal linear mixed\u2010effects model was used for data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four patients met the inclusion criteria for this study. Thirty\u2010two patients successfully completed aspirin desensitization and were subsequently followed for 30 months after desensitization. Two patients were unable to complete desensitization. Five patients discontinued aspirin maintenance therapy due to gastrointestinal and respiratory side effects. Within the follow\u2010up period, there were only 3 (9.4%) revision sinus surgeries. Notably, 1 of these revision cases occurred in a patient who had discontinued aspirin maintenance therapy. After surgical treatment and prior to desensitization patients had significant reductions in SNOT\u201022 scores. Our results demonstrate that total SNOT\u201022 scores remained statistically unchanged from immediate post\u2010desensitization throughout the 30\u2010month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Complete sinus surgery followed by timely aspirin desensitization and maintenance therapy is an effective combination in the long\u2010term management of sinus disease in patients with AERD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22036","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T15:15:34Z","timestamp":1509722134000},"page":"49-53","source":"Crossref","is-referenced-by-count":70,"title":["Outcomes after complete endoscopic sinus surgery and aspirin desensitization in aspirin\u2010exacerbated respiratory disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Nithin D.","family":"Adappa","sequence":"first","affiliation":[{"name":"Division of Rhinology Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viran J.","family":"Ranasinghe","sequence":"additional","affiliation":[{"name":"Division of Rhinology Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Trope","sequence":"additional","affiliation":[{"name":"Division of Rhinology Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Division of Rhinology Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan T.","family":"Glicksman","sequence":"additional","affiliation":[{"name":"North Shore ENT  Danvers MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun K.","family":"Parasher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of South Florida  Tampa FL"},{"name":"Leonard Davis Institute of Health Economics University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Division of Rhinology Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Bosso","sequence":"additional","affiliation":[{"name":"Division of Rhinology Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000331"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130708600715"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.016003432.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70123-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2048-x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2913"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814545750"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21541"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:24:2:159"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.05.020"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21826"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26377"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12131"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60692-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21739"}],"container-title":["International Forum of Allergy &amp; 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