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Kirklin Research\u00a0and\u00a0Education Foundation"],"award-info":[{"award-number":["Faculty Development Research Award","John W. Kirklin Research\u00a0and\u00a0Education Foundation"]}],"id":[{"id":"10.13039\/100011221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The ciprofloxacin\u2010coated sinus stent (CSS) has unique therapeutic potential to deliver antibiotics to the sinuses. The objective of this study is to evaluate the efficacy of the CSS stent in eliminating <jats:italic>Pseudomonas aeruginosa<\/jats:italic> infection in a rabbit model of sinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A ciprofloxacin\u2010eluting sinus stent was created by coating ciprofloxacin\/Eudragit RS100 on biodegradable poly\u2010D\/L\u2010lactic acid (2 mg). After analyzing in\u2010vitro inhibition of <jats:italic>P aeruginosa<\/jats:italic> (PAO\u20101 strain) biofilm formation, a total of 8 stents (4 shams, 4 CSSs) were placed unilaterally in rabbit maxillary sinuses via dorsal sinusotomy after inducing infection for 1 week with PAO\u20101. Animals were assessed 2 weeks after stent insertion with nasal endoscopy, sinus culture, computed tomography (CT) scan, histopathology, and scanning electron microscopy (SEM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PAO\u20101 biofilm formation was significantly reduced in vitro with exposure to the CSS (<jats:italic>p<\/jats:italic> &lt; 0.0001). Insertion of the stent in PAO\u20101\u2013infected rabbits for 2 weeks resulted in significant improvement in sinusitis according to endoscopy scoring (<jats:italic>p<\/jats:italic> &lt; 0.0001) and CT scoring (<jats:italic>p<\/jats:italic> &lt; 0.002). Histology and SEM revealed marked improvement in the structure of the mucosa and submucosa with no detection of biofilm structures in the CSS cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although this study had a small sample size, we identified robust therapeutic efficacy of the CSS by reducing bacterial load and biofilm formation of <jats:italic>P aeruginosa<\/jats:italic> in a preclinical model of sinusitis after placement for 2 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22081","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T14:12:48Z","timestamp":1516025568000},"page":"482-489","source":"Crossref","is-referenced-by-count":23,"title":["Preclinical therapeutic efficacy of the ciprofloxacin\u2010eluting sinus stent for <i>Pseudomonas aeruginosa<\/i> sinusitis"],"prefix":"10.1002","volume":"8","author":[{"given":"Do\u2010Yeon","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Alabama at Birmingham  Birmingham AL"},{"name":"Gregory Fleming James Cystic Fibrosis Research Center University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Jin","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin","family":"Mackey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Skinner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Weeks","sequence":"additional","affiliation":[{"name":"Department of 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