{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:53:34Z","timestamp":1789977214800,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid\u2010eluting sinus implant was designed to address these limitations in patients with recurrent polyposis after sinus surgery by delivering 1350 \u03bcg of mometasone furoate (MF) directly to the ethmoid sinus mucosa over approximately 90 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, sham\u2010controlled, double\u2010blind trial was undertaken in 300 adults with refractory chronic rhinosinusitis with NPs (CRSwNP), who were candidates for repeat surgery. Eligible patients were randomized (2:1) and underwent in\u2010office bilateral placement of 2 implants or a sham procedure. All patients used the MF INCS 200 \u03bcg once daily. Co\u2010primary efficacy endpoints were the change from baseline in nasal obstruction\/congestion score and bilateral polyp grade, as determined by an independent panel based on centralized, blinded videoendoscopy review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients treated with implants experienced significant reductions in both nasal obstruction\/congestion score (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0074) and bilateral polyp grade (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0073) compared to controls. At day 90, implants were also associated with significant reductions in 4 of 5 prespecified secondary endpoints compared to control: proportion of patients still indicated for repeat sinus surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0004), percent ethmoid sinus obstruction (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0007), nasal obstruction\/congestion (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0248), and decreased sense of smell (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0470), but not facial pain\/pressure (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.9130). One patient experienced an implant\u2010related serious adverse event (epistaxis).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Significant improvements over a range of subjective and objective endpoints, including a reduction in the need for sinus surgery by 61%, suggest that MF sinus implants may play an important role in management of recurrent NP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22084","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T11:02:49Z","timestamp":1516359769000},"page":"471-481","source":"Crossref","is-referenced-by-count":82,"title":["A phase 3 trial of mometasone furoate sinus implants for chronic sinusitis with recurrent nasal polyps"],"prefix":"10.1002","volume":"8","author":[{"given":"Robert C.","family":"Kern","sequence":"first","affiliation":[{"name":"Northwestern University  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Pablo","family":"Stolovitzky","sequence":"additional","affiliation":[{"name":"ENT of Georgia  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Silvers","sequence":"additional","affiliation":[{"name":"Madison ENT &amp; Facial Plastic Surgery  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameet","family":"Singh","sequence":"additional","affiliation":[{"name":"George Washington Medical Faculty Associates  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jivianne T.","family":"Lee","sequence":"additional","affiliation":[{"name":"Orange County Sinus Institute Southern California Permanente Medical Group  Irvine CA"},{"name":"Department of Head and Neck Surgery David Geffen School of Medicine University of California Los Angeles  Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Yen","sequence":"additional","affiliation":[{"name":"Bethlehem ENT  Bethlehem PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Alfred M.C.","family":"Iloreta","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis P.J.","family":"Langford","sequence":"additional","affiliation":[{"name":"Charlotte Eye ENT Associates  Concord NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Karanfilov","sequence":"additional","affiliation":[{"name":"Ohio Sinus Institute  Dublin OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith E.","family":"Matheny","sequence":"additional","affiliation":[{"name":"Collin County Ear Nose &amp; Throat  Frisco TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Stambaugh","sequence":"additional","affiliation":[{"name":"Intersect ENT Inc.  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