{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:01:16Z","timestamp":1771927276803,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108009"],"award-info":[{"award-number":["81420108009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400444"],"award-info":[{"award-number":["81400444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470678"],"award-info":[{"award-number":["81470678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630023"],"award-info":[{"award-number":["81630023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The role of nasal nitric oxide (NO) in the diagnosis of allergic rhinitis (AR) is controversial. The aim of this study was to identify factors that may affect levels of nasal NO in AR patients and evaluate the role of nasal NO in the diagnosis of AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010five AR patients and 31 healthy controls were enrolled in this study. AR symptom scores were assessed using the visual analog scale. Eosinophil cationic protein (ECP) was detected by enzyme\u2010linked immunoassay, nasal NO was measured using a chemiluminescence analyzer, and nasal airway resistance (NAR) was assessed by active anterior rhinomanometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nasal obstruction score, ECP, and NAR were found to be independently associated with nasal NO. Nasal NO level in patients with nasal obstruction score\u00a0&lt;7 (mild\u2010to\u2010moderate obstruction) was significantly increased compared with healthy subjects (282.1\u00a0\u00b1\u00a0122.6 vs 150.7\u00a0\u00b1 48.4 ppb; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), and significantly decreased in patients with nasal obstruction score\u00a0\u22657 (severe obstruction) (97.2\u00a0\u00b1\u00a052.2 vs 150.7\u00a0\u00b1\u00a048.4 ppb; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Nasal NO and ECP in secretion were positively correlated in patients with mild\u2010to\u2010moderate nasal obstruction (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.678), but not in patients with severe nasal obstruction (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.077). In patients with NAR &lt;0.65 Pa\/cm<jats:sup>3<\/jats:sup>\/s, the correlation coefficient was highest between NO and ECP (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.685). The areas under the receiver operating characteristic curve for nasal NO level were 0.878 and 0.939 in patients with nasal obstruction scores\u00a0&lt;7 and NAR\u00a0&lt;0.65\u00a0Pa\/cm<jats:sup>3<\/jats:sup>\/s, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nasal patency affects nasal NO level significantly, and may reflect the severity of nasal inflammation in AR patients with mild\u2010to\u2010moderate nasal obstruction, but not in patients with severe nasal obstruction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22087","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T14:03:57Z","timestamp":1516197837000},"page":"686-694","source":"Crossref","is-referenced-by-count":22,"title":["Nasal ventilation is an important factor in evaluating the diagnostic value of nasal nitric oxide in allergic rhinitis"],"prefix":"10.1002","volume":"8","author":[{"given":"Jing","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Beijing TongRen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Allergy Beijing TongRen Hospital Capital Medical University  Beijing China"},{"name":"Department of Otorhinolaryngology Beijing DiTan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfei","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Beijing TongRen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"He","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Allergy Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengshuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Beijing TongRen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Allergy Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-9884","authenticated-orcid":false,"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Beijing TongRen Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Allergy Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00315.2016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2009.01616.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1101132"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/2\/3\/030301"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00613.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.08.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01379.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810392667"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24590"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834eccaf"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2466"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900600758218"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-014-9591-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900902849897"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.047"},{"key":"e_1_2_7_19_1","first-page":"169","article-title":"Standardisation Committee on Objective Assessment of the Nasal Airway IRS, Ers. Consensus report on acoustic rhinometry and rhinomanometry","volume":"43","author":"Clement PA","year":"2005","journal-title":"Rhinology"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0691-y"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2015.36.3805"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.142107"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01328.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3777"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2012.5.4.228"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.05.014"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01093.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050231"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01044.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2001.00825.x"},{"key":"e_1_2_7_32_1","first-page":"337","article-title":"Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction","volume":"17","author":"Serrano C","year":"2007","journal-title":"J Invest Allergol Clin Immunol."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00098.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2016.09.007"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:30:20Z","timestamp":1695483020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,17]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/alr.22087"],"URL":"https:\/\/doi.org\/10.1002\/alr.22087","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,17]]}}}