{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:09:19Z","timestamp":1776467359288,"version":"3.51.2"},"reference-count":67,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic rhinitis, an immunoglobulin E inflammatory condition including nasal congestion, obstruction, sneezing, pruritus, and fatigue symptoms, has significant impact on quality of life and impairs sleep. Sleep\u2010disordered breathing (SDB) patients often have normal all\u2010night apnea\u2010hypopnea (AHI) or respiratory\u2010disturbance (RDI) indices on polysomnography (PSG). We hypothesized that the rapid eye motion\u2013respiratory disturbance index (REM\u2010RDI) may be a novel predictor of allergic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 100 patients compared REM\u2010RDI results in 67 allergen\u2010positive patients with 33 nonallergic patients who presented with nasal blockage. Subjects completed STOP\u2010Bang\u00a9, 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022)\u00a9, and Epworth Sleepiness Scale\u00a9 questionnaires and underwent skin\u2010prick testing (SPT) and PSGs including REM\u2010RDI values. Using multivariate logistic regression models, we evaluated relationships between allergic status and sleep parameters while controlling for possible confounders including body mass index (BMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using REM\u2010RDI as the outcome of interest, allergen\u2010positive patients were 3.92 times more likely to have REM\u2010RDI values in a moderate\/severe range (\u226515 events\/hour); and patients with moderate\/severe REM\u2010RDI values were more likely to be allergen positive (<jats:italic>p<\/jats:italic> &lt; 0.05). Allergic status was not significantly related to all\u2010night AHI, RDI, or REM\u2010AHI. BMI was not significantly related to REM\u2010RDI. STOP\u2010Bang\u00a9 was related to allergy status (<jats:italic>p<\/jats:italic> = 0.02) and REM\u2010RDI (<jats:italic>p<\/jats:italic> &lt; 0.01). Allergic patients had increased REM latency and less total amount of REM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We revealed significant bidirectional associations between allergen positivity and increased REM\u2010RDI values independent of BMI, AHI, RDI, and REM\u2010AHI. Allergic inflammation and REM\u2010RDI data may play important roles in diagnosing and treating fatigued SDB patients and as objective perioperative safety and outcomes measures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22099","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T14:52:07Z","timestamp":1519224727000},"page":"817-824","source":"Crossref","is-referenced-by-count":19,"title":["Clinical associations between allergies and rapid eye movement sleep disturbances"],"prefix":"10.1002","volume":"8","author":[{"given":"Shelley R.","family":"Berson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, School of Medicine New York Medical College  Valhalla NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn","family":"Klimczak","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat (Otolaryngology)\u2013Head and Neck Surgery Mount Sinai School of Medicine  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Prezio","sequence":"additional","affiliation":[{"name":"Department of Social Work University of Texas at Austin  Austin TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat (Otolaryngology)\u2013Head and Neck Surgery Mount Sinai School of Medicine  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology New York Eye and Ear Infirmary of Mt. 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