{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:31:07Z","timestamp":1780493467309,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is associated with productivity losses exceeding US$13 billion annually. Although pain is well known to significantly affect patient productivity in other diseases, its economic impact on CRS\u2010related lost productivity has not been examined. The objective of this study was to determine whether CRS\u2010related facial pain correlates with lost productivity in patients with CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy patients with CRS were enrolled in a cross\u2010sectional investigation. Patients with a history of systemic inflammatory disease, ciliary dysfunction, chronic pain syndromes, migraines, and fibromyalgia were excluded. Pain was measured using the Brief Pain Inventory Short Form (BPI\u2010SF) and the Short\u2010Form McGill Pain Questionnaire (SF\u2010MPQ). Presenteeism, absenteeism and lost work, and household and overall productivity were assessed. Regression analysis was performed to assess potential confounders, including depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pain as measured with BPI\u2010SF and SF\u2010MPQ total scores correlated with all domains of productivity losses. Overall, lost productivity was significantly correlated with pain (<jats:italic>R<\/jats:italic> range, 0.354\u20100.485; <jats:italic>p<\/jats:italic> &lt; 0.001). Presenteeism (reduced work efficiency) had the highest correlation with all of the overall pain scores (<jats:italic>R<\/jats:italic> range, \u22120.366 to \u22120.515; <jats:italic>p<\/jats:italic> &lt; 0.001). Lost household productivity time was the least affected by pain (<jats:italic>R<\/jats:italic> range, 0.267\u20100.389; <jats:italic>p<\/jats:italic> &lt; 0.05). These correlations remained statistically significant after regression analysis, which accounted for depression (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A significant correlation exists between CRS\u2010related facial pain and productivity losses in patients with CRS that is independent of depression. Facial pain has the strongest correlation with presenteeism, which is the main driver of productivity losses and indirect costs associated with CRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22128","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T12:12:40Z","timestamp":1523535160000},"page":"907-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The price of pain in chronic rhinosinusitis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7026-5819","authenticated-orcid":false,"given":"Kristine A.","family":"Smith","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah School of Medicine  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaelene","family":"Ashby","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah School of Medicine  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah School of Medicine  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Oakley","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah School of Medicine  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-5028","authenticated-orcid":false,"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah School of Medicine  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106002647"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2001.00514.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin12.087"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21539"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21664"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21843"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01187.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25180"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813487850"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000099999.27348.78"},{"key":"e_1_2_6_12_1","unstructured":"European Federation of IASP.Reflection process on chronic diseases in the ER\u2014the role of chronic pain.http:\/\/www.sip-platform.eu\/.2012. 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