{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:36:47Z","timestamp":1788565007469,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"OptiNose US, Inc"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inadequate efficacy of current intranasal steroids in chronic rhinosinusitis (CRS) is attributable to ineffective and\/or inconsistent drug delivery to target anatomic sites. A new exhalation delivery system with fluticasone (EDS\u2010FLU) may improve outcomes by significantly increasing superior\/posterior corticosteroid delivery. A study was conducted to assess the long\u2010term efficacy and safety outcomes of EDS\u2010FLU in individuals with CRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a 12\u2010month, multicenter, single\u2010arm study evaluating the safety and efficacy of EDS\u2010FLU 372 \u03bcg twice daily in CRS patients (with [n = 34] or without [n = 189] nasal polyps [NP]). Efficacy assessments by serial nasal endoscopy and patient report included: 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022), NP grade, standardized surgical indicator assessment, Lund\u2010Kennedy score, and Patient Global Impression of Change. Adverse event (AE) evaluations included nasal endoscopy. Additional safety and efficacy outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 223 patients who received EDS\u2010FLU, 96% reported prior corticosteroid use and 29% prior sinus surgery. The EDS\u2010FLU AE profile was similar to conventional intranasal steroids studied in similar populations. Most patients (87%) reported symptom improvement. Through 12 months, mean SNOT\u201022 scores improved by \u221221.5 and \u221221.1 for CRS with and without NP, respectively. Among patients with NP, 54.2% had polyp elimination in at least 1 nostril and 83.3% had \u22651\u2010point improvement in polyp grade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Over 1 year of treatment in CRS with and without NP, EDS\u2010FLU 372 \u03bcg twice daily was well tolerated and produced improvements across a broad range of objective and subjective measures. EDS\u2010FLU may be a desirable new option for patients with this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22141","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T10:24:39Z","timestamp":1527848679000},"page":"869-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["EXHANCE\u201012: 1\u2010year study of the exhalation delivery system with fluticasone (EDS\u2010FLU) in chronic rhinosinusitis"],"prefix":"10.1002","volume":"8","author":[{"given":"James N.","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania, Perelman School of Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kraig W.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Oregon Allergy Associates  Eugene OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Messina","sequence":"additional","affiliation":[{"name":"OptiNose US, Inc.  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