{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:34:13Z","timestamp":1776270853499,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T00:00:00Z","timestamp":1529712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal undifferentiated carcinoma (SNUC) is a very rare entity with a poor prognosis. Due to the lack of studies on the subject, evidence is lacking concerning its management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter collaborative study was conducted to assess treatment strategy, oncological outcome, and prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Definitive analyses focused on 54 patients with a majority of advanced stage; the 3\u2010year overall survival (OS) and 3\u2010year recurrence\u2010free survival (RFS) rates were, respectively, 62.4% and 47.8%. During the follow\u2010up, 18 patients (33.3%) died, 10 (18.5%) developed metastases, 7 had lymph\u2010node involvement (13%), and 12 (22.2%) showed recurrence or local progression. In univariate analyses, treatment modalities associated with improved RFS were induction chemotherapy (<jats:italic>p<\/jats:italic> = 0.02) and intensity\u2010modulated radiotherapy (<jats:italic>p<\/jats:italic> = 0.007). In the multivariate analyses, only induction chemotherapy (<jats:italic>p<\/jats:italic> = 0.047, hazard ratio [HR] = 0.39) was significantly associated with improved RFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multimodal therapies including induction chemotherapy and intensity\u2010modulated radiotherapy may improve the prognosis of SNUC; surgery might improve local control. Further multicenter studies are required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22143","type":"journal-article","created":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T09:54:21Z","timestamp":1529747661000},"page":"1065-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Clinical characteristics and prognostic factors of sinonasal undifferentiated carcinoma: a multicenter study"],"prefix":"10.1002","volume":"8","author":[{"given":"Guillaume","family":"de Bonnecaze","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Rangueil\u2010Larrey  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Verillaud","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Lariboisi\u00e8re  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Chaltiel","sequence":"additional","affiliation":[{"name":"Biostatistics Department L'Institut Universitaire du Cancer de Toulouse\u2010Oncopole (IUCT\u2010Oncopole) Cancer Institute  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvestre","family":"Fierens","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Pellegrin  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Chapelier","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Rangueil\u2010Larrey  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Rumeau","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital of Nancy  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Malard","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Gavid","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Saint\u2010Etienne  Saint\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Dufour","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Poitiers  Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Righini","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Grenoble  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Uro\u2010coste","sequence":"additional","affiliation":[{"name":"Department of Pathology, IUCT\u2010Oncop\u00f4le Cancer Institute  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Rives","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, IUCT\u2010Oncop\u00f4le Cancer Institute  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Bach","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Hopital Foch  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Baujat","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Tenon 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