{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:01:34Z","timestamp":1790488894651,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic conjunctivitis (AC) is a common chronic condition, especially in children. Ocular symptoms are often overlooked during treatment of allergic rhinoconjunctivitis (ARC). Pediatric ARC can be effectively treated using sublingual immunotherapy (SLIT), which is a guideline\u2010recommended safe treatment approach. However, the therapeutic efficacy of SLIT in terms of ameliorating eye symptoms has not been effectively evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a meta\u2010analysis of randomized controlled trials (RCTs) evaluating the use of SLIT for infants, children, and adolescents (aged from 3 to 18 years) with AC or ARC. We searched the Cochrane Library database, EMBASE, and Medline from November 1990 to 2017 to find papers dealing with the effects of SLIT on pediatric AC or ARC. We used standardized mean differences (SMDs) to assess therapeutic effects, employing a random effects model. Subgroup and sensitivity analyses were also conducted. The <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> metric was used to evaluate heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 13 clinical RCTs were included in our meta\u2010analysis. SLIT reduced ocular symptoms to a level below that of controls (SMD = \u22120.21; 95% confidence interval [CI], \u22120.41 to \u22120.01; <jats:italic>p<\/jats:italic> = 0.04; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 55%). Notably, on subgroup analysis, SLIT clearly reduced pollen\u2010induced pediatric AC (SMD = \u22120.36; 95% CI, \u22120.53 to \u22120.19; <jats:italic>p<\/jats:italic> &lt; 0.0001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 25%) but not mite\u2010induced AC (SMD = 0.20; 95% CI, \u22120.20 to 0.60; <jats:italic>p<\/jats:italic> = 0.34; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 46%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLIT relieved ocular symptoms in children with ARC or AC. To confirm these results, future meta\u2010analyses should evaluate high\u2010quality, large\u2010scale population\u2010based trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22149","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T13:19:31Z","timestamp":1526908771000},"page":"1253-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sublingual immunotherapy for pediatric allergic conjunctivitis: a meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"8","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Zhejiang Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Zhejiang Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Zhejiang Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1040760"},{"key":"e_1_2_6_3_1","first-page":"35","article-title":"Treating the ocular component of allergic rhinoconjunctivitis and related eye disorders","volume":"9","author":"Bielory L","year":"2007","journal-title":"MedGenMed"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.12.011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60681-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01548.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03224.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2009.09.011"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2016.8.3.191"},{"issue":"91","key":"e_1_2_6_10_1","first-page":"1","article-title":"Sub\u2010lingual immunotherapy: World Allergy Organization position paper 2009","volume":"64","author":"Canonica GW","year":"2009","journal-title":"Allergy"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01622.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01402.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03835.x"},{"key":"e_1_2_6_14_1","first-page":"277","article-title":"Efficacy of sublingual immunotherapy in patients with rhinitis and asthma due to house dust mite. 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