{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:15:40Z","timestamp":1781010940908,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Aspirin\u2010exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic rhinosinusitis, nasal polyps, asthma, and respiratory sensitivity to aspirin and nonsteroidal anti\u2010inflammatory drugs (NSAIDs). In addition to sensitivity to aspirin and NSAIDs, the majority of patients with AERD have been reported to have respiratory intolerance associated with the consumption of alcohol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter prospective cohort study was performed. Patients with AERD confirmed by aspirin challenge were eligible to participate. Those who described themselves as able to tolerate alcohol consumption were excluded. Patients underwent aspirin desensitization following endoscopic sinus surgery. A questionnaire was distributed to patients before and after desensitization to determine pre\u2010desensitization and post\u2010desensitization symptoms associated with alcohol ingestion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients were enrolled and 37 patients completed the study. The most common pre\u2010desensitization symptoms were nasal congestion (95.6%), rhinorrhea (46.7%), and wheezing (40%). Improvement in the ability to tolerate alcohol was noted in 86.5% of participants (95% confidence interval [CI], 75.5% to 97.5%) and 70.3% of participants (95% CI, 55.5% to 85.0%) described desensitization to be \u201cvery helpful\u201d or \u201cextremely helpful\u201d for their ability to tolerate alcohol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of patients with AERD who experience respiratory symptoms with alcohol consumption describe improvement in this domain following aspirin desensitization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22168","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T09:56:43Z","timestamp":1531562203000},"page":"1093-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Alcohol\u2010induced respiratory symptoms improve after aspirin desensitization in patients with aspirin\u2010exacerbated respiratory disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Jordan T.","family":"Glicksman","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Philadelphia PA"},{"name":"Department of Otolaryngology Harvard Medical School, Massachusetts Eye and Ear Infirmary  Boston MA"},{"name":"North Shore ENT  Danvers MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun K.","family":"Parasher","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Philadelphia PA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of South Florida  Tampa FL"},{"name":"Department of Health Policy and Management University of South Florida  Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Doghramji","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brauer","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, &amp; Immunology Scripps Clinic and Research Foundation  San Diego CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Waldram","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, &amp; Immunology Scripps Clinic and Research Foundation  San Diego CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Walters","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, &amp; Immunology Scripps Clinic and Research Foundation  San Diego CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Bulva","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, &amp; Immunology Scripps Clinic and Research Foundation  San Diego CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"White","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, &amp; 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