{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:01:28Z","timestamp":1784800888142,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T00:00:00Z","timestamp":1532736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intranasal corticosteroid (INCS) is the most efficacious medicine for treating chronic rhinitis. A decongestant and INCS combination (INCS\u2010D) is considered for nasal congestion that is not improved by INCS. This study aimed to investigate the effects of INCS\u2010D on chronic rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature searches were performed using MEDLINE and EMBASE. Randomized controlled trials studying the effects of INCS\u2010D vs INCS alone for treating chronic rhinitis were included. Data were pooled for meta\u2010analysis. Outcomes were nasal symptoms, disease\u2010specific quality of life, objective tests for nasal patency, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies (1071 patients) met the inclusion criteria. There were no differences between INCS\u2010D and INCS on total nasal symptom scores (standardized mean difference [SMD] \u22120.85; 95% confidence interval [CI], \u22122.09 to 0.40; <jats:italic>p<\/jats:italic> = 0.18), nasal congestion scores (SMD \u22120.13; 95% CI, \u22120.46 to 0.20; <jats:italic>p<\/jats:italic> = 0.43), and the Rhinoconjunctivitis Quality of Life Questionnaire score (SMD \u22120.12; 95% CI, \u22120.66 to 0.42; <jats:italic>p<\/jats:italic> = 0.66). After 1 week, there were no differences on objective tests for nasal patency (acoustic rhinometry: SMD 0.04; 95% CI, \u22120.68 to 0.76, <jats:italic>p<\/jats:italic> = 0.91; and peak nasal inspiratory flow: SMD 0.08; 95% CI, \u22120.16 to 0.32; <jats:italic>p<\/jats:italic> = 0.52). Adverse events were not different between INCS\u2010D and INCS (risk ratio 1.09; 95% CI, 0.73 to 1.62).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Meta\u2010analyses did not show benefits of topical decongestants addition to INCS. Adverse events of INCS\u2010D were comparable with INCS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22193","type":"journal-article","created":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T18:33:06Z","timestamp":1532802786000},"page":"1445-1453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of decongestant addition to intranasal corticosteroid for chronic rhinitis: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"8","author":[{"given":"Likhit","family":"Khattiyawittayakun","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Otolaryngology Maharat Nakhon Ratchasima Hospital  Nakhon Ratchasima Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-7638","authenticated-orcid":false,"given":"Kachorn","family":"Seresirikachorn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Endoscopic Nasal and Sinus Surgery Excellence Center King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wirach","family":"Chitsuthipakorn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Sawan Pracharak Hospital  Nakhonsawan Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dichapong","family":"Kanjanawasee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Endoscopic Nasal and Sinus Surgery Excellence Center King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7537-4718","authenticated-orcid":false,"given":"Kornkiat","family":"Snidvongs","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Endoscopic Nasal and Sinus Surgery Excellence Center King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0720-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2015.7.6.534"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.07.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814561600"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900513"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.5.6.783"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb04877.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2012.09.005"},{"key":"e_1_2_6_11_1","unstructured":"HigginsJPT GreenS editors.Cochrane Handbook for Systematic Reviews of Interventions. version 5.1.0 [updated March 2011]. 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