{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:02:21Z","timestamp":1790622141358,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with eosinophilic chronic rhinosinusitis (ECRS) have been shown to have greater disease severity and poorer treatment outcomes after sinus surgery. Although the inflammatory pattern of ECRS is essential to diagnosing this subtype, there is currently no consensus for diagnosis. Our aim in this study was to determine whether high tissue eosinophilia (HTE), measured as eosinophils per high\u2010power field (eos\/HPF), could be used to define ECRS based on likelihood of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Embase, Medline, and PubMed databases were searched for studies that reported HTE and recurrence in ECRS patients after surgical treatment. We used a random\u2010effects bivariate meta\u2010analysis to calculate summary sensitivity, specificity, and diagnostic odds ratios (DORs) for detecting ECRS at different HTE cut\u2010off scores using risk of recurrence as the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 11 articles (n = 3183) that reported HTE associated with recurrence. A cut\u2010off value of &gt;55 eos\/HPF showed the highest sensitivity (0.87; 95% confidence interval [CI], 0.82\u20100.91), specificity (0.97; 95% CI, 0.93\u20100.99), and DOR (232.7; 95% CI, 91.0\u2010595.1). Meta\u2010regression analysis performed showed that the Quality Assessment of Diagnostic Accuracy Studies score (<jats:italic>p<\/jats:italic> = 0.1287), geographic location (<jats:italic>p<\/jats:italic> = 0.3745), follow\u2010up time (<jats:italic>p<\/jats:italic> = 0.2879), and study design (<jats:italic>p<\/jats:italic> = 0.1865) did not affect the test accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that using eos\/HPF has good diagnostic accuracy and may be a useful tool for identifying ECRS patients. Based on the results of our meta\u2010analysis, we recommend a cut\u2010off value of &gt;55 eos\/HPF for predicting the likelihood of recurrence of ECRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22194","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T15:04:56Z","timestamp":1533827096000},"page":"1421-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["High tissue eosinophilia as a marker to predict recurrence for eosinophilic chronic rhinosinusitis: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"8","author":[{"given":"Tobial","family":"McHugh","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology, Head and Neck Surgery McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornkiat","family":"Snidvongs","sequence":"additional","affiliation":[{"name":"Division 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