{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:37:16Z","timestamp":1769607436156,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003572","name":"American Academy of Otolaryngic Allergy Foundation","doi-asserted-by":"publisher","award":["Joint Clinical Research Award"],"award-info":[{"award-number":["Joint Clinical Research Award"]}],"id":[{"id":"10.13039\/100003572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010485","name":"American Rhinologic Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010485","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Earlier studies have suggested that patients with chronic rhinosinusitis (CRS) report worse sleep quality than population norms. What remains unknown is whether these patients are actually experiencing measurable changes in objective sleep parameters. The goal of this study was to prospectively evaluate objective sleep measures in a cohort of patients with CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, multi\u2010institutional, case\u2010control study was designed to compare patients with CRS to nondiseased controls. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (EpSS). Home sleep studies were administered across all subjects and a battery of objective sleep measurements were recorded using a portable sleep diagnostic device. Regression models were used to control for any factors that differed across groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 108 subjects were enrolled across 4 institutions, including 52 patients with CRS and 56 controls. Total PSQI scores were worse in patients with CRS when compared with controls (10.1 \u00b1 4.3 vs 4.7 \u00b1 2.5; <jats:italic>p<\/jats:italic> &lt; 0.001). Similarly, daytime somnolence, as measured by the EpSS, was greater in patients with CRS (9.1 \u00b1 5.3 vs 6.5 \u00b1 3.7; <jats:italic>p<\/jats:italic> = 0.006). On home sleep studies, patients with CRS were found to have an increased number of awakenings during a night's sleep (8.6 \u00b1 4.8 vs 6.3 \u00b1 3.0; <jats:italic>p<\/jats:italic> = 0.004), lower average overnight oxygen saturation (93.2 \u00b1 2.6% vs 94.3 \u00b1 2.1%; <jats:italic>p<\/jats:italic> = 0.042), increased rapid eye movement sleep (REMS) latency (93.0 \u00b1 67.1 vs 66.7 \u00b1 35.3; <jats:italic>p<\/jats:italic> = 0.016), and spent a greater portion of the night snoring at &gt;40 dB (24.7 \u00b1 27.4% vs 14.6 \u00b1 19.7%; <jats:italic>p<\/jats:italic> = 0.034). All differences except mean oxygen saturation remained significant after controlling for baseline differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Differences in both patient\u2010reported and objective sleep measures exist between patients with CRS and controls.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22212","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T15:33:54Z","timestamp":1538753634000},"page":"16-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Impact of chronic rhinosinusitis on sleep: a controlled clinical study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-5028","authenticated-orcid":false,"given":"Jeremiah A.","family":"Alt","sequence":"first","affiliation":[{"name":"Sinus and Skull Base Surgery Program, Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-0705","authenticated-orcid":false,"given":"Vijay R.","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Colorado  Aurora CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Boston University  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery, Department of Otolaryngology\u2013Head &amp; Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Storck","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery, Department of Otolaryngology\u2013Head &amp; Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery, Department of Otolaryngology\u2013Head &amp; Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21695_c"},{"issue":"243","key":"e_1_2_6_3_1","first-page":"1","article-title":"Summary health statistics for the U.S. population: National Health Interview Survey, 2008","volume":"10","author":"Adams PF","year":"2009","journal-title":"Vital Health Stat"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21860"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24040"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21364"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817737977"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21488"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21408"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161208786549281"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_6_15_1","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9769-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/15.4.376"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000093487.78664.3C"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.8.1560"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.5.923"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.3.695"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00111-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.3.367"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/28\/2\/002"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/29\/5\/004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2012.11.001"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.03.008"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1324"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53839-0.00003-X"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2005.05.002"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.06.017"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22099"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24019"}],"container-title":["International Forum of Allergy &amp; 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