{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:06:01Z","timestamp":1775534761234,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multidimensional disease. In this study, we performed an unsupervised cluster analysis of CRSwNP using routinely available clinical markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of patients treated with endoscopic sinus surgery due to medically intractable bilateral CRSwNP from 2009 to 2017. Unsupervised cluster analysis was performed using a patient's clinical features, including age, peripheral blood eosinophil, tissue eosinophilia, Lund\u2010Mackay computed tomography (CT) scores, ratio of the CT scores for the ethmoid sinus and maxillary sinus (E\/M ratio), and comorbid asthma. Tree analysis was performed to develop a clustering algorithm. Kaplan\u2010Meier survival analysis was performed to determine the revision surgery\u2013free probability corresponding to each cluster.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were available on 375 patients. Patients were categorized into 6 clusters comprising 2 asthmatic clusters and 4 non\u2010asthmatic clusters. The labels for the 2 asthmatic clusters were: asthmatic non\u2010eosinophilic polyp (cluster A1) and asthmatic eosinophilic polyp (cluster A2). The labels for the 4 non\u2010asthmatic clusters were: non\u2010eosinophilic polyp with older age (cluster NA1); non\u2010eosinophilic pol'yp with younger age (cluster NA2); eosinophilic polyp with lower E\/M ratio (cluster NA3); and eosinophilic polyp with higher E\/M ratio (cluster NA4). The 4\u2010year revision\u2010free rates were 100% (cluster NA1), 80.3% (NA2), 98.0% (NA3), 66.7% (NA4), 100% (A1), and 66.7% (A2). The clusters showed statistically significant differences in terms of 4\u2010year revision\u2010free rates (log\u2010rank <jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cluster analysis identified 2 asthmatic clusters and 4 non\u2010asthmatic clusters in CRSwNP. Each cluster corresponded to a different clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22221","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T15:33:05Z","timestamp":1538753585000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Unsupervised cluster analysis of chronic rhinosinusitis with nasal polyp using routinely available clinical markers and its implication in treatment outcomes"],"prefix":"10.1002","volume":"9","author":[{"given":"Jeong\u2010Whun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of 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