{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:42:21Z","timestamp":1778042541724,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7172054"],"award-info":[{"award-number":["7172054"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent sinonasal mucosa inflammatory disease. MicroRNAs (miRNAs) that are involved in the pathogenesis of CRSwNP in Northern China remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A miRCURY\u2122 LNA Array was used to analyze miRNA profiles in nasal mucosa tissues of CRSwNP patients (n = 19) and healthy controls (n = 10). Subsequent pathways were predicted by DIANA\u2010mirPath software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five upregulated miRNAs, including miR\u2010210\u20105p, miR\u20103178, miR\u2010585\u20103p, miR\u20103146, and miR\u2010320e, and 19 downregulated miRNAs, including miR\u201032\u20103p, miR\u20101299, miR\u20103196, miR\u20103924, and miR\u2010548e\u20103p, were differentially expressed (<jats:italic>p<\/jats:italic> &lt; 0.05, fold change &gt;2) in tissues of CRSwNP vs controls. Utilizing the Kyoto Encyclopedia of Genes and Genomes database (KEGG), which is an online database for pathway mapping, mucin type O\u2010glycan biosynthesis pathway was significantly enriched in upregulated miRNAs. Transforming growth factor\u2010beta (TGF\u2010\u03b2), transient receptor potential (TRP) channels, and the mitogen\u2010activated protein kinase (MAPK) signaling pathway were significantly linked to downregulated miRNAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mucin type O\u2010glycan biosynthesis pathway and TGF\u2010\u03b2 signaling pathway are regulated by miRNAs, which could be our focus in the future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22230","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T08:45:51Z","timestamp":1540975551000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["MicroRNAs regulating mucin type O\u2010glycan biosynthesis and transforming growth factor \u03b2 signaling pathways in nasal mucosa of patients with chronic rhinosinusitis with nasal polyps in Northern China"],"prefix":"10.1002","volume":"9","author":[{"given":"Lijia","family":"Xuan","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-9884","authenticated-orcid":false,"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology  Beijing China"},{"name":"Department of Allergy, Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,31]]},"reference":[{"issue":"23","key":"e_1_2_6_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol 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