{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:17:53Z","timestamp":1789039073236,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Obstructive sleep\n apnea is a common respiratory disorder that can have negative effects on health and quality of life. Positive pressure therapy (CPAP) is the primary treatment. There is a lack of consensus on the risk of postoperative CPAP after endoscopic sinus or skull base surgery. We present a proof\u2010of\u2010concept cadaver model for measuring sinonasal pressure delivered by CPAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three fresh cadaver heads were prepared by removing the calvaria and brain. Sphenoidotomies were made and sellar bone was removed. Pressure sensors were placed in the midnasal cavity, sphenoid sinus, and sella. CPAP was applied and the delivered pressure was recorded at increasing levels of positive pressure. Paired <jats:italic>t<\/jats:italic> tests and intraclass correlation coefficients were used to analyze results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increases in positive pressure led to increased pressure recordings for all locations. Nasal cavity pressure was, on average, 81% of delivered CPAP. Pressure was highest in the sphenoid sinus. The effect of middle turbinate medialization on intrasphenoid pressure was not statistically significant in 2 heads. Intrasellar pressure was 80% of delivered CPAP with lateralized turbinates and 84% with medialized turbinates. Pressure recordings demonstrated excellent reliability for all locations. All heads developed non\u2012sellar\u2010based cranial base leaks at higher pressures. Cribriform region leaks were successfully sealed with DuraSeal\u00ae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our proof\u2010of\u2010concept cadaver model represents a novel approach to measure pressures delivered to the nasal cavity and anterior skull base by CPAP. With further study, it may have broader clinical application to guide the safe postoperative use of CPAP in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22235","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T23:21:10Z","timestamp":1542324070000},"page":"197-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A cadaveric model for measuring sinonasal continuous positive airway pressure\u2014a proof\u2010of\u2010concept study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-8183","authenticated-orcid":false,"given":"Ryan A.","family":"Rimmer","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandala","family":"Chitguppi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermes G.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Koszewski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurston G.","family":"Nyquist","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Huntley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy R.","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Thomas Jefferson University Hospital  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1079","article-title":"Sleep apnea as an independent risk factor for all\u2010cause mortality: the Busselton Health Study","volume":"31","author":"Marshall NS","year":"2008","journal-title":"Sleep"},{"key":"e_1_2_5_3_1","first-page":"1071","article-title":"Sleep disordered breathing and mortality: eighteen\u2010year follow\u2010up of the Wisconsin sleep cohort","volume":"31","author":"Young T","year":"2008","journal-title":"Sleep"},{"key":"e_1_2_5_4_1","first-page":"920","article-title":"Epidemiological aspects of obstructive sleep apnea","volume":"7","author":"Garvey JF","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818771540"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92140-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25336"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22066"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2016.01.012"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26731"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.2.279"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2015.09.005"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2015.03.015"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20013"}],"container-title":["International Forum of Allergy &amp; 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