{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:35:21Z","timestamp":1780590921043,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Intersect ENT"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Bioabsorbable steroid\u2010releasing implants (mometasone furoate, 370 \u03bcg) are effective for improving postsurgical outcomes in the frontal sinus ostia (FSO). In this study we evaluated the effect of these implants on frontal outcomes in various patient subgroups with chronic rhinosinusitis (CRS) using pooled data from 2 randomized, controlled trials (RCTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 160 subjects were enrolled in 2 RCTs. After surgery, subjects were randomized to receive an implant in 1 FSO with the contralateral side as control. Data through day 90 from the 2 studies were pooled and subgroup analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At day 30, relative to controls, steroid\u2010releasing implants significantly reduced the need for postoperative interventions by 46.8% (95% confidence interval [CI], \u221260.7 to \u221227.9), for surgical interventions by 51.2% (95% CI, \u221268.2 to \u221225.2), and for oral steroid interventions by 37.2% (95% CI, \u221254.6 to \u221213.1) in the pooled data set. At day 90, statistically significant reductions (<jats:italic>p<\/jats:italic> &lt; 0.05) in the need for postoperative interventions (relative reduction [RR], 30.2%), restenosis\/occlusion rate (RR, 31.7%), and inflammation score (absolute difference, \u22126.0), and increase in estimated FSO diameter (absolute difference, 1 mm), favoring the treated side, were observed. Subgroup analyses of the pooled data showed statistically significant improvements (<jats:italic>p<\/jats:italic> &lt; 0.05) at day 90 in restenosis\/occlusion rate, and estimated FSO diameter, favoring the treated side across subgroups, with no statistically significant subgroup\u2010by\u2010treatment interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bioabsorbable steroid\u2010releasing sinus implants improve outcomes of frontal sinus surgery through 90 days, irrespective of asthma status, previous endoscopic sinus surgery, extent of surgery, extent of polyps, or Lund\u2010Mackay computed tomography stage in the FSO.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22238","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T23:19:28Z","timestamp":1542323968000},"page":"131-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Bioabsorbable steroid\u2010releasing implants in the frontal sinus ostia: a pooled analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Ameet","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Otolaryngology George Washington University Medical Center  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber U.","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery McGovern Medical School at the University of Texas Health Science Center  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J.","family":"Fong","sequence":"additional","affiliation":[{"name":"California Sinus Centers  Walnut Creek CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall A.","family":"Ow","sequence":"additional","affiliation":[{"name":"Sacramento ENT  Roseville CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Han","sequence":"additional","affiliation":[{"name":"Divisions of Rhinology and Endoscopic Sinus\u2010Skull Base Surgery and Allergy Eastern Virginia Medical School  Norfolk VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Gerencer","sequence":"additional","affiliation":[{"name":"BreatheAmerica  Albuquerque NM"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Pablo","family":"Stolovitzky","sequence":"additional","affiliation":[{"name":"ENT of Georgia  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W","family":"Stambaugh","sequence":"additional","affiliation":[{"name":"Intersect ENT, Inc  Menlo Park CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarthi","family":"Raman","sequence":"additional","affiliation":[{"name":"Intersect ENT, Inc  Menlo Park CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2017.1281740"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.03.022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00797.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3758"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00515.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20168"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000202086.18206.C8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-1810(10)80087-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21708"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.05.010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24422"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26140"},{"key":"e_1_2_7_16_1","article-title":"Safety and effectiveness of a bioabsorbable steroid\u2010releasing implant for the paranasal sinus ostia: a randomized clinical trial","author":"Luong A","journal-title":"JAMA Otolaryngol Head Neck Surg."},{"key":"e_1_2_7_17_1","article-title":"Frontal sinus drug\u2010eluting implants\u2014effective, but for which patients and at what cost","author":"Gray ST","journal-title":"JAMA Otolaryngol Head Neck Surg."},{"key":"e_1_2_7_18_1","first-page":"S1","article-title":"Clinical practice guideline (update): adult sinusitis","volume":"152","author":"Rosenfeld RM","year":"2015","journal-title":"Otolaryngol Head Neck Surg."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2016.03.024"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065897781446793"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21044"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415573959"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31818208c1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126066"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000182825.82910.80"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21109"}],"container-title":["International Forum of Allergy &amp; 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