{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:26:59Z","timestamp":1784068019564,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the tremendous burden of smell and taste dysfunction in patients with chronic rhinosinusitis (CRS), objective measures of smell and taste fail to fully account for eating\u2010related disruptions in CRS patient quality of life (QOL). In this study we sought to investigate the driving force behind impaired eating\u2010related QOL in CRS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult CRS patients were prospectively enrolled and answered a series of surveys relating to smell, taste, overall sinus\u2010specific QOL, and depression. Patients with both smell\u2010related and taste\u2010related eating complaints were considered to have impaired eating\u2010related QOL. Clinical demographics, objective chemosensory scores, and endoscopy scores were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy patients were enrolled and 23% showed impaired eating\u2010related QOL. In multivariable analyses, patients with aspirin\u2010exacerbated respiratory disease (AERD) showed 10.7 times higher odds of impaired eating\u2010related QOL (odds ratio [OR] 10.72; 95% confidence interval [CI], 1.09 to 105.09; <jats:italic>p<\/jats:italic> = 0.042); meanwhile, for every 1\u2010point increase in depression scores, the odds of impaired eating\u2010related QOL increased by 1.3 (OR 1.31; 95% CI, 1.10 to 1.57; <jats:italic>p<\/jats:italic> = 0.003). For every 1\u2010point decrease in orthonasal olfactory threshold, the odds of impaired eating\u2010related QOL increased by 1.9 times (OR 1.85; 95% CI, 1.14 to 3.00; <jats:italic>p<\/jats:italic> = 0.013). Symptom scores, polyp status, endoscopic scores, and other olfactory measures did not remain significant after adjusting for other variables in forward\u2010selection multivariable modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Disruptions in eating\u2010related QOL cannot be fully explained by objective smell or taste testing alone. We identified AERD and depression as independent risk factors for greater odds of impaired eating\u2010related QOL in CRS. Improved orthonasal threshold scores were independently associated with better eating\u2010related QOL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22242","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T18:40:32Z","timestamp":1543430432000},"page":"240-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Impaired eating\u2010related quality of life in chronic rhinosinusitis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1296-2648","authenticated-orcid":false,"given":"Nicholas R.","family":"Rowan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Rhinology and Sinus Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Rhinology and Sinus Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina A.","family":"Storck","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Rhinology and Sinus Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Othieno","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Rhinology and Sinus Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia G.","family":"Ganjaei","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Rhinology and Sinus Surgery Medical University of South Carolina  Charleston SC"},{"name":"Rutgers Robert Wood Johnson Medical School Rutgers University  Piscataway NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-7083","authenticated-orcid":false,"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Rhinology and Sinus\/Skull Base Surgery Oregon Health &amp; Science University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Rhinology and Sinus Surgery Medical University of South Carolina  Charleston SC"},{"name":"Department of Surgery Ralph H. Johnson VA Medical Center  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00032"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3210-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21679"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21940"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22112"},{"key":"e_1_2_6_7_1","article-title":"Retronasal olfaction in chronic rhinosinusitis","author":"Othieno F","journal-title":"Laryngoscope"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22113"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21841"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3286"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199813000-00015"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510410s02"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21655"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01155.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000093487.78664.3C"},{"key":"e_1_2_6_17_1","first-page":"146","article-title":"A test for the screening of taste function","volume":"35","author":"Hummel T","year":"1997","journal-title":"Rhinology"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200311000-00026"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.4.414"},{"key":"e_1_2_6_20_1","first-page":"2","article-title":"Quantitative assessment of gustatory function in a clinical context using impregnated \u201ctaste strips\u201d","volume":"41","author":"Mueller C","year":"2003","journal-title":"Rhinology"},{"key":"e_1_2_6_21_1","volume-title":"Performing Exact Logistic Regression with the SAS System \u2014 Revised 2009","author":"Derr RE","year":"2009"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.03.001"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4366-x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892418770260"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-014-0064-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12131"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8050080"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.142"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjw061"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3459-06.2006"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T08:44:22Z","timestamp":1694681062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,28]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/alr.22242"],"URL":"https:\/\/doi.org\/10.1002\/alr.22242","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,28]]},"assertion":[{"value":"2018-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}