{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:34:31Z","timestamp":1783049671980,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102018\u2010R1D1A1A02085328"],"award-info":[{"award-number":["NRF\u20102018\u2010R1D1A1A02085328"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102017R1C1B1007696"],"award-info":[{"award-number":["NRF\u20102017R1C1B1007696"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate the relations between gastroesophageal reflux disease (GERD) and chronic rhinosinusitus (CRS) in a Korean population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects from the Korean National Health Insurance Service\u2012National Sample Cohort, all \u226520 years old, were assessed from 2002 to 2013. In total, 23,489 CRS participants were matched with 93,956 controls at a ratio of 1:4 with respect to age, group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed previous history of GERD in the CRS and control groups. The CRS group included patients identified using International Classification of Diseases 10th edition (ICD\u201010) codes (J32) who had treated their CRS \u22652 times and had undergone head and neck computed tomography (CT). The GERD group included patients identified using the ICD\u201010 (K21) code who had treated their GERD \u22652 times and had taken a proton pump inhibitor (PPI) for \u22652 weeks. Crude and adjusted odds ratios (ORs) were analyzed using unconditional logistic regression analyses. The 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of GERD was higher in the CRS group (17.1% [4020 of 23,489]) than in the control group (9.1% [8522 of 93,956]; <jats:italic>p<\/jats:italic> &lt; 0.001). The adjusted OR of GERD was 2.04 (95% CI, 1.96\u20102.13; <jats:italic>p<\/jats:italic> &lt; 0.001) in the CRS group. The results of the subgroup analyses were consistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ORs of GERD were increased in CRS participants. This relationship was consistent in all age and sex groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22259","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T11:39:38Z","timestamp":1544441978000},"page":"357-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Gastroesophageal reflux disease increases the risk of chronic rhinosinusitis: a nested case\u2010control study using a national sample cohort"],"prefix":"10.1002","volume":"9","author":[{"given":"So Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery CHA Bundang Medical Center, CHA University  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bumjung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Hallym University College of Medicine  Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine  Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Hallym University College of Medicine  Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Gyu","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Hallym University College of Medicine  Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-9549","authenticated-orcid":false,"given":"Hyo Geun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Hallym University College of Medicine  Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06921.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306393"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183808"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino50E2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"e_1_2_7_10_1","first-page":"1","article-title":"Summary health statistics for U.S. adults: National Health Interview Survey, 2005","volume":"232","author":"Pleis JR","year":"2006","journal-title":"Vital Health Stat 10"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168498"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21553"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin16.275"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23738"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001642"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4167"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000163751.00885.63"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/2152656718764233"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4193\/Rhino10.054","article-title":"Is there evidence to link acid reflux with chronic sinusitis or any nasal symptoms? 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