{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:32:50Z","timestamp":1771327970853,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03\u00a0DC014809"],"award-info":[{"award-number":["R03\u00a0DC014809"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["L30\u00a0AI113795"],"award-info":[{"award-number":["L30\u00a0AI113795"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CTSA\u00a0Award\u00a0UL1TR000445"],"award-info":[{"award-number":["CTSA\u00a0Award\u00a0UL1TR000445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>It is hypothesized that uncontrolled inflammation is responsible for many of the manifestations and symptoms of chronic rhinosinusitis (CRS). Although earlier work has demonstrated an association between olfactory loss and mucus cytokines, the impact on other symptoms is unknown. In this study we investigated the relationship between cytokines, inflammatory cell counts, and patient\u2010reported outcomes measures to better understand how the inflammatory microenvironment correlates with CRS symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) and 8\u2010item Short Form Health Survey (SF\u20108) were administered to 76 patients undergoing endoscopic sinus surgery for CRS. Mucus was collected intraoperatively from the middle meatus and tested for 17 cytokines using a multiplex flow cytometric bead assay. Eosinophil\/neutrophil counts were obtained from histopathologic slide review. Spearman correlations between cytokines, cell counts, and quality\u2010of\u2010life subdomain scores were assessed without multiple comparisons correction due to the small sample size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interleukin\u20104 (IL\u20104) correlated significantly with the Rhinologic domain (R<jats:sub>s<\/jats:sub> = 0.25, <jats:italic>p<\/jats:italic> = 0.03), whereas eosinophil and neutrophil counts were inversely correlated with the Extranasal Rhinologic domain (R<jats:sub>s<\/jats:sub> = \u22120.32, <jats:italic>p<\/jats:italic> = 0.01; and R<jats:sub>s<\/jats:sub> = \u22120.27, <jats:italic>p<\/jats:italic> = 0.03). Subgroup analysis for nasal polyposis (CRSwNP) showed significant correlations between IL\u20106 and Total SF\u20108 (R<jats:sub>s<\/jats:sub> = 0.35, <jats:italic>p<\/jats:italic> = 0.02), General Health (R<jats:sub>s<\/jats:sub> = 0.34, <jats:italic>p<\/jats:italic> = 0.03), and Emotional (R<jats:sub>s<\/jats:sub> = 0.47, <jats:italic>p<\/jats:italic> = 0.002) scores. In patients without polyps (CRSsNP), IL\u201021 correlated positively with Extranasal Rhinologic Symptoms domain (R<jats:sub>s<\/jats:sub> = 0.41, <jats:italic>p<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot study identifies possible pairwise correlations between mucus cytokine levels and baseline quality\u2010of\u2010life measures that need confirmation in larger, targeted studies. Due to the exploratory methodology, positive results may be spurious and should only be used as a starting point for future confirmatory work.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22287","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T17:18:09Z","timestamp":1547140689000},"page":"538-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Investigating the correlation between mucus cytokine levels, inflammatory cell counts, and baseline quality\u2010of\u2010life measures in chronic rhinosinusitis"],"prefix":"10.1002","volume":"9","author":[{"given":"Naweed I.","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery Vanderbilt University School of Medicine  Nashville TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh K.","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery Vanderbilt University School of Medicine  Nashville TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery Vanderbilt University School of Medicine  Nashville TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Ely","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, Immunology Vanderbilt University School of Medicine  Nashville TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin H.","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery Vanderbilt University School of Medicine  Nashville TN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21695_c"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900518"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21183"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.085"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21943"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21636"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27112"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.0927"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22160"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22196"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.002"},{"issue":"23","key":"e_1_2_6_13_1","first-page":"3","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21408"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22028"},{"key":"e_1_2_6_16_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.11.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12781"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-1031-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02316.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.072"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.06.014"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2014.07.009"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24412"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481435"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.05.018"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.09.021"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.15412\/J.BCN.03070207"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.11.024"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24305"}],"container-title":["International Forum of Allergy &amp; 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