{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:05:18Z","timestamp":1778691918535,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Olfactory nerve fibers are at risk of injury during transnasal endoscopic skull\u2010base approaches. Olfactory outcomes for various techniques have not been thoroughly investigated. This study aims to report long\u2010term olfactory outcomes when a cold knife upper septal limb incision technique is used compared to monopolar cautery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was performed at a tertiary referral center. Adult patients undergoing endoscopic approaches with septal incisions were randomized to cold knife or monopolar cautery groups. Patient demographics, clinical history, surgical data, and outcomes were collected. Preoperative, 3\u2010month, and 12\u2010month postoperative scores on the University of Pennsylvania Smell Inventory Test (UPSIT) and 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) were measured. Fisher's exact tests were performed for categorical variables and <jats:italic>t<\/jats:italic> tests were performed for continuous variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two (22) patients (10 cold knife, 12 cautery) were enrolled between March 2016 and August 2017. The average age \u00b1 standard deviation was 50.2 \u00b1 14.0 years (<jats:italic>p<\/jats:italic> = 0.59), 54% (<jats:italic>p<\/jats:italic> = 0.69) were female, and the primary pathology was pituitary adenoma (73%, <jats:italic>p<\/jats:italic> = 1.00). Preoperative, 3\u2010month, and 12\u2010month postoperative UPSIT scores were similar between the cold knife and cautery groups (32.8 vs 32.4, <jats:italic>p<\/jats:italic> = 0.80; 33.1 vs 33.0, <jats:italic>p<\/jats:italic> = 0.96; 33.6 vs 33.3, <jats:italic>p<\/jats:italic> = 0.84). On the \u201csense of smell\/taste\u201d question of the SNOT\u201022, there was also no difference at all time points (<jats:italic>p<\/jats:italic> &gt; 0.22).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no significant change in patient UPSIT scores 1 year after transnasal skull\u2010base approaches, and no short\u2010term or long\u2010term differences between cold knife and cautery upper septal limb incision techniques. Our study supports an individualized approach based on surgeon preference.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22291","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T15:25:10Z","timestamp":1547825110000},"page":"493-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Long\u2010term olfaction outcomes in transnasal endoscopic skull\u2010base surgery: a prospective cohort study comparing electrocautery and cold knife upper septal limb incision techniques"],"prefix":"10.1002","volume":"9","author":[{"given":"Cassandra L.","family":"Puccinelli","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-2051","authenticated-orcid":false,"given":"Linda X.","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin K.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie J.","family":"Van Gompel","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garret W.","family":"Choby","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn M.","family":"Van Abel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Janus","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janalee K.","family":"Stokken","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21760"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21069"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21890"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.5.497"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20824"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003000-00016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21856"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26546"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000234933.37779.e4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21419"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24107"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4109"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24674"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21103"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24037"},{"key":"e_1_2_7_17_1","volume-title":"The Smell Identification Test Administration Manual","author":"Doty RL","year":"2008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(84)90269-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198402000-00004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318282a535"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.09.032"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1554905"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4206"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242983"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.6.JNS111066"}],"container-title":["International Forum of Allergy &amp; 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