{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:07:29Z","timestamp":1789168049772,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300815"],"award-info":[{"award-number":["81300815"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570310000"],"award-info":[{"award-number":["81570310000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2014BAI07B04"],"award-info":[{"award-number":["2014BAI07B04"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known regarding the role of the microbiome of the paranasal sinuses and its contribution to sinus mucosal health and disease. Consequently, we examined the microbiome of chronic rhinosinusitis patients with polyps (CRSwNP) and a control population to provide new insights into the microbiota associated with the pathogenesis of CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010nine CRSwNP patients and 27 controls were enrolled in the study. The bacterial communities of the middle meatus were detected using 16S ribosomal RNA (rRNA)\u2012targeted Illumina MiSeq sequencing after microbial DNA was extracted from swabs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although there was no difference in diversity between the 2 groups, richness was lower in the CRSwNP group than in the control group (<jats:italic>p<\/jats:italic> = 0.03). At the phylum level, <jats:italic>Firmicutes<\/jats:italic>, <jats:italic>Proteobacteria<\/jats:italic>, <jats:italic>Actinobacteria<\/jats:italic>, and <jats:italic>Bacteroidetes<\/jats:italic> were predominant in both groups; however, the relative abundance was different, with the proportions of <jats:italic>Actinobacteria<\/jats:italic> (predominantly <jats:italic>Corynebacterium<\/jats:italic>) and <jats:italic>Dolosigranulum<\/jats:italic> being significantly higher in the control group than in the CRSwNP group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results support the theory of microbial dysbiosis as the pathogenesis of CRSwNP. The reduction in the proportions of potentially protective bacteria may decrease the overall stability of the sinonasal bacterial community.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22297","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T16:19:58Z","timestamp":1549383598000},"page":"582-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The difference in nasal bacterial microbiome diversity between chronic rhinosinusitis patients with polyps and a control population"],"prefix":"10.1002","volume":"9","author":[{"given":"Weigang","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery West China Hospital, West China School of Medicine, Sichuan University  Chengdu Sichuan PR China"},{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery West China Hospital, West China School of Medicine, Sichuan University  Chengdu Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Nanchong Central Hospital  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danmei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Qing","sequence":"additional","affiliation":[{"name":"Department of General Practice Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery West China Hospital, West China School of Medicine, Sichuan University  Chengdu Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery West China Hospital, West China School of Medicine, Sichuan University  Chengdu Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery West China Hospital, West China School of Medicine, Sichuan University  Chengdu Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery West China Hospital, West China School of Medicine, Sichuan University  Chengdu Sichuan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2006.0019"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130408301217"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130208100712"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200404000-00032"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000113"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2016.03.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00621.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/326411a0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12666"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003783"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21600"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00134"},{"key":"e_1_2_6_14_1","first-page":"3","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01520-08"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.133"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13632"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0266-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.02.008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21626"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21871"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01225.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-75"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.02.023"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.5465"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085507"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.1999.0680"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001500"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201407-1240OC"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201401-0073OC"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin17.240"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02637.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.01.033"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00057"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22297","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T12:22:38Z","timestamp":1694348558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/alr.22297"],"URL":"https:\/\/doi.org\/10.1002\/alr.22297","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]},"assertion":[{"value":"2018-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}