{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:03:15Z","timestamp":1777341795384,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Staphylococcus pseudintermedius<\/jats:italic> is a Gram\u2010positive bacteria that colonizes the skin and orifices of healthy canines and felines. It has recently been identified as a cause of sinonasal infections in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a retrospective review of chronic rhinosinusitis (CRS) patients with <jats:italic>S pseudintermedius<\/jats:italic>\u2012positive sinonasal cultures and comparison to a prospectively collected control sample of patients who underwent culture for acute exacerbation of CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients with CRS had nasal cultures positive for <jats:italic>S pseudintermedius<\/jats:italic>. Of the positive cultures, 82% demonstrated resistance to penicillin, 58% to clindamycin, 45% to trimethoprim\u2010sulfamethoxazole, 33% to doxycycline, and 27% to oxacillin. Ninety\u2010seven percent of patients with <jats:italic>S pseudintermedius<\/jats:italic> were dog owners. There was no significant difference in age, gender, recent endoscopic sinus surgery, or immunosuppression or deficiency between <jats:italic>S pseudintermedius<\/jats:italic> patients and patients undergoing culture for acute exacerbation of CRS, but <jats:italic>S pseudintermedius<\/jats:italic> infection was associated with dog ownership (<jats:italic>p<\/jats:italic> &lt; 0.01). <jats:italic>S pseudintermedius<\/jats:italic> infection was not associated with behaviors such as a dog sleeping in the bedroom, routinely licking humans, or being diagnosed with a soft tissue infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although a rare cause of infection in humans, <jats:italic>S pseudintermedius<\/jats:italic> should be considered in sinonasal infections refractory to standard medical management, especially if the patient has regular contact with dogs. <jats:italic>S pseudintermedius<\/jats:italic> is not readily identified with routine laboratory 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