{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:39:33Z","timestamp":1761863973747,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intranasal steroids have become part of the mainstay in the long\u2010term management of chronic rhinosinusitis. A long\u2010standing problem remains in efficient and easy\u2010to\u2010use delivery of topical corticosteroids to the nasal mucosa. Currently available means of intranasal steroid delivery include sprays, which are generally limited to treating the anterior nasal cavity, and rinses, which are not FDA\u2010approved for this indication. The exhalation delivery system is a novel method of delivering fluticasone to the deeper areas within the nasal cavities, including the posterior nasal cavity and middle and superior meatuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Comprehensive literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recent large scale studies have suggested its efficacy and safety in the use of patients with both chronic sinusitis with polyposis and without polyps. Specifically, studies have demonstrated decreased Sinonasal Outcome Test scores of 20 points following treatment, as well as improvement of polyp grade by 1 or more point in more than 60% of patients. Furthermore, among patients with nasal polyps, there was approximately 60\u201070% decreased indication for surgery following EDS\u2010FLU use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EDS\u2010FLU is an important adjunct therapy for sinonasal inflammatory disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22340","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T09:31:22Z","timestamp":1557826282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of fluticasone exhalation delivery system in the management of chronic rhinosinusitis: what is the evidence?"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0718","authenticated-orcid":false,"given":"Edward C.","family":"Kuan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery University of California  Irvine Medical Center Orange CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery University of California  Irvine Medical Center Orange CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan D.","family":"Workman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery Massachusetts Eye and Ear Infirmary  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John V.","family":"Bosso","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2012Head and Neck Surgery University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2012Head and Neck Surgery University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-7-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13042"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000701"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25180"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0540-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21172"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21096"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21724"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21695_c"},{"issue":"8","key":"e_1_2_7_13_1","first-page":"CD009274","article-title":"Topical steroid for chronic rhinosinusitis without polyps","author":"Snidvongs K","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.04.020"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880080012004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2011.0924"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000199741.08517.99"},{"key":"e_1_2_7_18_1","first-page":"69","article-title":"Videoendoscopic analysis of nasal steroid distribution","volume":"37","author":"Weber R","year":"1999","journal-title":"Rhinology"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2009.07.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3950"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3880"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21700"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40136-012-0003-4"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22034"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.260"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.261"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22141"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892418810281"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.010"},{"key":"e_1_2_7_30_1","unstructured":"VelezFF SacksH MessinaJC RadewonukJ MahmoudR YardleyP.Impact of EDS\u2010FLU on work productivity: results from two phase III trials Navigate 1 and 2. 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