{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:25:45Z","timestamp":1786976745083,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, represents up to 3% of all sinonasal neoplasms. Hyams histologic grading is a promising tool in predicting metastases and establishing prognoses for this complex tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was performed in the PubMed, Ovid MEDLINE, and Cochrane databases. ENB patients with Hyams I\u2010II or III\u2010IV were categorized as low\u2010grade Hyams (LGH) or high\u2010grade Hyams (HGH), respectively. Binary and continuous random\u2010effects models were applied to calculate odds ratios (ORs) for the incidences of neck and distal metastases as well as for 5\u2010 and 10\u2010year overall survival rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 57 screened articles published from 1993 to 2018, 16 (525 patients) and 21 (563 patients) provided data for tumor metastases and overall survival rates, respectively. Neck metastasis was observed in 18.2% of HGH vs 7.9% of LGH patients. Distant metastasis was noted in 20.7% of HGH vs 8.9% of LGH patients. LGH patients had 5\u2010 and 10\u2010year overall survival rates of 81.2% and 64.0%, respectively, as compared with 60.9% and 40.6%, respectively, for HGH patients. In comparing HGHs vs LGHs, the collective ORs for neck and distant metastases were 2.08 (95% confidence interval [CI], 1.09\u20103.99;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03) and 2.37 (95% CI, 1.07\u20105.26;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03), respectively. Moreover, in comparing LGHs vs HGHs, collective ORs for 5\u2010 and 10\u2010year overall survival rates were 3.39 (95% CI, 2.09\u20105.49;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and 3.03 (95% CI, 1.82\u20105.06;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HGH ENBs, compared with LGH ENBs, are more likely to metastasize to neck or distal targets and to have lower overall survival rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22373","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T16:05:05Z","timestamp":1561737905000},"page":"1054-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Hyams grading as a predictor of metastasis and overall survival in esthesioneuroblastoma: a meta\u2010analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Khodayar","family":"Goshtasbi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Abiri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Abouzari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Sahyouni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby A.","family":"Tajudeen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank P. 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