{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:39:44Z","timestamp":1790444384065,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Primary sinonasal mucoepidermoid carcinoma (SN\u2010MEC) is a malignancy arising from seromucinous glands of the nasal cavity and paranasal sinuses. Given its rarity, few large\u2010scale studies have been performed. In this study we describe the incidence and determinants of survival of patients with SN\u2010MEC leveraging the National Cancer Database (NCDB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, population\u2010based cohort study of patients diagnosed with SN\u2010MEC between 2004 and 2012 within the NCDB. The main outcome measure was overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 164 patients were identified. The cohort was composed of 47.6% males. Mean age at diagnosis was 59.7 years. The maxillary sinus was the most common primary site, accounting for 45.7% of cases. Eleven percent of patients presented with nodal disease, whereas 2.1% had distant metastases. Stage IV disease was seen in 30.4% of cases. A total of 79.8% of the patients underwent surgery, 61.0% received radiation therapy, and 15.1% had chemotherapy. OS at 1, 2, and 5 years was 83%, 77.0%, and 57%, respectively. On multivariate analysis, Medicaid insurance status (hazard ratio [HR], 7.29; 95% confidence interval [CI], 1.74\u201030.57), advanced tumor size (HR, 4.94; 95% CI, 1.19\u201020.5), and advanced nodal disease (N1: HR, 9.48; 95% CI, 1.66\u201054.23; N2B: HR, 19.3; 95% CI, 1.07\u2010350.64) were associated with worse OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mucoepidermoid carcinoma is the most common salivary gland malignancy but a rare sinonasal malignancy, with 5\u2010year survival for SN\u2010MEC approximating 50%. A significant proportion of patients present with advanced disease. Both socioeconomic factors and tumor characteristics are associated with survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22379","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T17:19:40Z","timestamp":1563383980000},"page":"1046-1053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sinonasal mucoepidermoid carcinoma: a review of the National Cancer Database"],"prefix":"10.1002","volume":"9","author":[{"given":"Vasiliki","family":"Triantafillou","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2012Head and Neck Surgery Perelman School of Medicine, University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-2718","authenticated-orcid":false,"given":"Ivy W.","family":"Maina","sequence":"additional","affiliation":[{"name":"Department of 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