{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:12:15Z","timestamp":1770534735382,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K11369"],"award-info":[{"award-number":["JP17K11369"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In this study, we aimed to determine whether nasal thallium\u2010201 uptake of the olfactory cleft and olfactory bulb (OB) differs between patients with parosmia with and without hyposmia after upper respiratory tract infection (URTI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients with parosmia after URTI were enrolled in this study (15 women and 5 men, 28 to 76 years old). Nasally administered thallium\u2010201 migration to the OB, nasal thallium\u2010201 uptake ratio in the olfactory cleft, and OB volume were determined in 10 patients with normal T&amp;T olfactometry (Daiichi Yakuhin Sangyo, Tokyo, Japan) odor recognition thresholds (\u22642.0) who still complained of parosmia (parosmia group), and 10 patients with T&amp;T odor recognition thresholds &gt;2.0 (parosmia and hyposmia group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The nasal thallium\u2010201 uptake ratio in the olfactory cleft was significantly higher in the parosmia group than in the parosmia and hyposmia group (<jats:italic>p<\/jats:italic> = 0.0015). Thallium\u2010201 migration to the OB was not significantly different between the 2 groups (<jats:italic>p<\/jats:italic> = 0.31). The OB volume was significantly larger in the parosmia group than that in the parosmia and hyposmia group (<jats:italic>p<\/jats:italic> = 0.029); however, the mean OB volume in both the groups was lower than the normal threshold value in healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results signify the recovery of the olfactory epithelium; however, the olfactory neural projections to the OB and regeneration of OB were not complete in patients with parosmia with normal T&amp;T recognition thresholds after URTI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22395","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T16:53:32Z","timestamp":1564419212000},"page":"1252-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nasal thallium\u2010201 uptake in patients with parosmia with and without hyposmia after upper respiratory tract infection"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7218-154X","authenticated-orcid":false,"given":"Hideaki","family":"Shiga","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Physics Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Graduate School of Medical Science Kanazawa University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Radiology Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Tonami","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Radiology Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seigo","family":"Kinuya","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Graduate School of Medical Science Kanazawa University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaki","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0157-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-010-0461-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057671"},{"key":"e_1_2_7_5_1","first-page":"3","article-title":"Olfactory bulb volume in the clinical assessment of olfactory dysfunction","volume":"47","author":"Rombaux P","year":"2009","journal-title":"Rhinology"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03894-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/27.7.611"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.01.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjh150"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/26.8.971"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12849"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001773"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0796-y"},{"key":"e_1_2_7_15_1","first-page":"58","volume-title":"Management of Smell and Taste Disorders: A Practical Guide for Clinicians","author":"Hummel T","year":"2013"}],"container-title":["International Forum of Allergy &amp; 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