{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:50:51Z","timestamp":1789541451441,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005640","name":"Flight Attendant Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005640","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is a common condition that has been associated with cognitive dysfunction. The purpose of this study was to evaluate the effect of endoscopic sinus surgery (ESS) on the subjective and objective measures of cognitive dysfunction and related quality\u2010of\u2010life measures in CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five adults with CRS refractory to medical therapy were prospectively enrolled. Preoperatively and postoperatively (\u22654 months), subjects completed objective neurocognitive evaluation with the Automated Neuropsychological Assessment Metrics (ANAM) platform and multiple questionnaires, including the Cognitive Failures Questionnaire (CFQ), a modified World Health Organization Health and Work Performance Questionnaire (ctHPQ), 22\u2010item Sino\u2010Nasal Outcomes Test (SNOT\u201022), Sinus Control Test (SCT), Questionnaire of Olfactory Disorders (QOD), Beck Depression Inventory\u2015second edition (BDI\u2010II), Pittsburgh Sleep Quality Index (PSQI), and Fatigue Severity Scale (FSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three of 35 patients satisfactorily completed the study. Postsurgical improvement in the CFQ was 46.7 \u00b1 18.4 to 31.9 \u00b1 17.8 (<jats:italic>p<\/jats:italic> &lt; 0.001). Neurocognitive testing revealed significant improvements in mathematical processing (<jats:italic>p<\/jats:italic> = 0.003) and matching to sample (<jats:italic>p<\/jats:italic> = 0.023), as well as a significant decline in simple reaction time (<jats:italic>p<\/jats:italic> = 0.026). In addition, improvements were noted for SNOT\u201022 (54.8 \u00b1 21.4 to 24.8 \u00b1 21.1, <jats:italic>p<\/jats:italic> &lt; 0.001), SCT (9.3 \u00b1 2.6 to 3.9 \u00b1 3.8, <jats:italic>p<\/jats:italic> &lt; 0.001), PSQI (10.7 \u00b1 4.5 to 6.9 \u00b1 4.0, <jats:italic>p<\/jats:italic> &lt; 0.001), BDI\u2010II (14.0 \u00b1 9.9 to 8.9 \u00b1 9.0, <jats:italic>p<\/jats:italic> &lt; 0.001), QOD (17.6 \u00b1 13.4 to 9.9 \u00b1 12.3, <jats:italic>p<\/jats:italic> = 0.001), and FSS (4.6 \u00b1 1.4 to 3.1 \u00b1 1.5, <jats:italic>p<\/jats:italic> &lt; 0.001). There was significant improvement in overall presenteeism (7.3 \u00b1 1.4 to 8.4 \u00b1 1.3, <jats:italic>p<\/jats:italic> = 0.029). Analysis by polyp status revealed significant improvement in mathematical processing and matching to sample in only CRS patients without polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ESS is associated with improvement in subjective and some aspects of objective cognition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22406","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T17:15:21Z","timestamp":1566839721000},"page":"1135-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of endoscopic sinus surgery on objective and subjective measures of cognitive dysfunction in chronic rhinosinusitis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-8869","authenticated-orcid":false,"given":"Frederick","family":"Yoo","sequence":"first","affiliation":[{"name":"Division of Rhinology and Sinus Surgery, Department of Otolaryngology\u2012Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery, Department of Otolaryngology\u2012Head and Neck Surgery Medical University of South Carolina  Charleston SC"},{"name":"Department of Surgery Ralph H. 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