{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:07:57Z","timestamp":1774584477001,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08AI146220"],"award-info":[{"award-number":["K08AI146220"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["ROWE15R0"],"award-info":[{"award-number":["ROWE15R0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000850","name":"National Heart and Lung Institute","doi-asserted-by":"publisher","award":["1 R01 HL133006\u201004"],"award-info":[{"award-number":["1 R01 HL133006\u201004"]}],"id":[{"id":"10.13039\/501100000850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5P30DK072482\u201002"],"award-info":[{"award-number":["5P30DK072482\u201002"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010485","name":"American Rhinologic Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010485","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mucociliary clearance is a main defense mechanism of the airway and is impaired in ciliary dyskinesia. The objective of this study was to evaluate the prevalence of chronic rhinosinusitis (CRS) and its characteristics in bronchiectasis patients suspected of harboring ciliary dyskinesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bronchiectasis patients referred to a rhinology clinic for nasal brush biopsy (NBB) were included in this study. NBB was performed using a curettage technique whereby ciliated epithelial cells were obtained from the surface of the inferior nasal turbinate. Results of transmission electron microscopy findings, primary ciliary dyskinesia (PCD) gene (35 genes) analyses (Invitae), and sinus computed tomography (CT) scans were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three patients (age, 54 \u00b1 2.9 years) were referred for NBB between 2015 and 2018. Thirteen patients (56.5%) met the criteria for diagnosis of CRS. Nineteen patients had ciliary ultrastructural defects. The most common finding was compound cilia (n = 11, 47.8%). Five patients (21.7%) had central microtubule defects (CMD) with higher forced expiratory volume in 1 second (FEV<jats:sub>1<\/jats:sub>) at the time of referral than those without CMD (CMD<jats:sup>+<\/jats:sup>, 91 \u00b1 3.7%; CMD<jats:sup>\u2212<\/jats:sup>, 73.5 \u00b1 5.7%; <jats:italic>p<\/jats:italic> = 0.023). Of 15 subjects with a PCD gene panel, 67% (9 of 15) carried at least 1 gene associated with PCD. Only 1 patient reached diagnosis of PCD. Approximately 50% of non\u2010PCD carriers had a smoking history (<jats:italic>p<\/jats:italic> &lt; 0.05). Lund\u2010Mackay scores did not significantly differ between PCD and non\u2010PCD carriers (<jats:italic>p<\/jats:italic> = 0.72).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nearly half of bronchiectasis patients referred for NBB had concurrent CRS. The presence of ciliary abnormalities was not amplified in bronchiectasis patients with CRS compared to those without CRS. Extrinsic factors may be related to ciliary structural abnormalities in non\u2010PCD gene carriers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22414","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T16:11:23Z","timestamp":1566317483000},"page":"1430-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of chronic rhinosinusitis in bronchiectasis patients suspected of ciliary dyskinesia"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-4976","authenticated-orcid":false,"given":"Justin P.","family":"McCormick","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Weeks","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Rivers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob D.","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital of Alabama  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center University of Alabama at Birmingham  Birmingham AL"},{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham AL"},{"name":"Department of Pediatrics University of Alabama at Birmingham  Birmingham AL"},{"name":"Department of Cell Developmental and Integrative Biology University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Gregory Fleming James Cystic Fibrosis Research Center University of Alabama at Birmingham  Birmingham AL"},{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradford A.","family":"Woodworth","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery University of Alabama at Birmingham  Birmingham AL"},{"name":"Gregory Fleming James Cystic Fibrosis Research Center University of Alabama at Birmingham  Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-8959","authenticated-orcid":false,"given":"Do\u2010Yeon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery University of Alabama at Birmingham  Birmingham AL"},{"name":"Gregory Fleming James Cystic Fibrosis Research Center University of Alabama at Birmingham  Birmingham 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