{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:31:26Z","timestamp":1774866686638,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Well\u2010known allergy tests are used to evaluate and diagnose allergic diseases. The aim of this study was to assess the role of serum level diamine oxidase (DAO) enzyme as a diagnostic marker in respiratory allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2010control study included 40 patients with respiratory allergies (atopic asthma and allergic rhinitis) as well as 40 age\u2010 and sex\u2010matched controls. A detailed past medical history of allergy was collected from each participant including family history of allergy. Physical examination, pulmonary function test (PFT) and measurement of serum levels of total immunoglobulin E (IgE) and DAO were performed. Skin\u2010prick test and specific IgE to common aeroallergens were also carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DAO levels were higher in patients than controls. There was a positive correlation between severity of disease and DAO. No significant association was found between DAO level and age, type of respiratory allergy, duration of disease, PFT, eosinophilia, and total IgE. DAO had a high negative predictive value (94.7%) and high sensitivity (97.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DAO may be helpful in the assessment of severity and in ruling out respiratory allergy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22426","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T17:10:36Z","timestamp":1568826636000},"page":"1478-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diamine oxidase enzyme: a novel biomarker in respiratory allergy"],"prefix":"10.1002","volume":"9","author":[{"given":"Maged M.","family":"Refaat","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Allergy and Clinical Immunology Ain Shams University Faculty of Medicine  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa S.","family":"Abdel\u2010Rehim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Allergy and Clinical Immunology Ain Shams University Faculty of Medicine  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira R.","family":"Elmahdi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Allergy and Clinical Immunology Ain Shams University Faculty of Medicine  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrine A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Immunology Ain Shams University Faculty of Medicine  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara S.","family":"Ghonaim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Allergy and Clinical Immunology Ain Shams University Faculty of Medicine  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"7","volume-title":"EFA Book on Respiratory Allergies: Raise Awareness, Relieve the Burden","author":"Valovirta E","year":"2011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-003-0049-y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i19.2851"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-75840-9_14"},{"key":"e_1_2_6_6_1","first-page":"53","volume-title":"Histamine: Biology and Medical Aspects","author":"Schwelberger HG","year":"2004"},{"key":"e_1_2_6_7_1","first-page":"253","article-title":"Cellular allergen stimulation test (CAST) 2003, a review","volume":"14","author":"De Weck AL","year":"2004","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03572.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.049"},{"key":"e_1_2_6_10_1","volume-title":"Global strategy for asthma management and prevention","author":"Global Initiative for Asthma (GINA)","year":"2019"},{"key":"e_1_2_6_11_1","first-page":"1","article-title":"National asthma education and prevention program","volume":"3","author":"National Heart, Lung, and Blood Institute","year":"2007","journal-title":"Expert Panel Report"},{"key":"e_1_2_6_12_1","first-page":"168","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet J","year":"2008","journal-title":"Allergy"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8561(05)70207-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7361.414"},{"key":"e_1_2_6_16_1","first-page":"8","volume-title":"Dacie and Lewis Practical Haematology","author":"Bates I","year":"2016"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X112552"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.03.034"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.23664.x"},{"issue":"73","key":"e_1_2_6_20_1","first-page":"23","article-title":"The co\u2010morbidity of allergic hay fever and asthma in randomly selected patients with respiratory allergic diseases","volume":"57","author":"Jacobsen L","year":"2002","journal-title":"Allergy"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.45.141"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0394632015617170"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13361"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-013-0354-y"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.05.020"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13663"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2015.01.009"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2015.455"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.037"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80181-2"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2002.077"},{"issue":"6","key":"e_1_2_6_32_1","first-page":"543","article-title":"Practice parameters for allergy diagnostic testing. Joint Task Force on Practice Parameters representing the American Academy of Allergy, Asthma & Immunology, the American College of Allergy, Asthma and Immunology, and the Joint Council on Allergy, Asthma and Immunology","volume":"75","author":"Bernstein IL","year":"1995","journal-title":"Ann Allergy Asthma Immunol"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60305-5"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-006-0021-8"},{"key":"e_1_2_6_35_1","first-page":"202","article-title":"Comparison of serum specific IgE with skin prick test in the diagnosis of allergy in Malaysia","volume":"66","author":"Asha'ari Z","year":"2011","journal-title":"Med J Malaysia"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01965105"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2016.02.025"},{"key":"e_1_2_6_38_1","first-page":"49","article-title":"Association of polymorphisms of two histamine\u2010metabolizing enzymes with allergic asthma in Egyptian children","volume":"13","author":"Khalifa DS","year":"2015","journal-title":"Egypt J Pediatr Allergy Immunol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02769.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.9734\/BJMMR\/2011\/711"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22426","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T12:48:03Z","timestamp":1694177283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/alr.22426"],"URL":"https:\/\/doi.org\/10.1002\/alr.22426","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]},"assertion":[{"value":"2019-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}