{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:13:13Z","timestamp":1791807193141,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A short\u2010course oral corticosteroid taper and topical intranasal corticosteroids may be used to maximize the success of medical management for chronic rhinosinusitis with nasal polyps (CRSwNP). In this study, we sought to identify characteristics that would be predictive of efficacy for this combination regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010four patients with CRS, bilateral polyps, a polyp score of at least 3, and a 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) score \u226520 were prospectively enrolled and uniformly treated with a 15\u2010day prednisone taper and twice daily dilute budesonide irrigations. Participants were assessed at enrollment and at follow up, 2 to 5 months later. Clinical and demographic characteristics were assessed at enrollment. At both time points, CRS symptoms were assessed with SNOT\u201022, and polyp score (range, 0 to 6) was assessed endoscopically. Associations were determined with regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pretreatment SNOT\u201022 score (adjusted \u03b2 = \u22120.83; 95% CI, \u22121.08 to \u22120.58; <jats:italic>p<\/jats:italic> &lt; 0.001) and comorbid asthma (adjusted \u03b2 = 15.75; 95% CI, 4.74 to 26.75; <jats:italic>p<\/jats:italic> = 0.007) were associated with a change in SNOT\u201022 experienced over the study period. Achieving a greater\u2010than\u20101 minimal clinically important difference (MCID) improvement in SNOT\u201022 score was also associated with pretreatment SNOT\u201022 score (adjusted OR = 1.09; 95% CI, 1.04 to 1.14; <jats:italic>p<\/jats:italic> &lt; 0.001) and comorbid asthma (adjusted OR = 0.13; 95% CI, 0.03 to 0.72; <jats:italic>p<\/jats:italic> = 0.019). SNOT\u201022 score \u226547 had 81.5% sensitivity and 78.4% specificity to detect patients experiencing 1 MCID improvement. Pretreatment polyp score was not associated with any outcome metric.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In treatment of CRSwNP with prednisone and budesonide irrigations, pretreatment endoscopy was not informative of treatment response. Pretreatment SNOT\u201022 and comorbid asthma may be more predictive.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22431","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T10:00:36Z","timestamp":1571047236000},"page":"1436-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Predictors of efficacy for combination oral and topical corticosteroids to treat patients with chronic rhinosinusitis with nasal polyps"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0887-5111","authenticated-orcid":false,"given":"Madison V.","family":"Epperson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Stanford University  Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Caradonna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School  Boston MA"},{"name":"Division of Otolaryngology Beth Israel Deaconess Medical Center  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School  Boston MA"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-2325","authenticated-orcid":false,"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati 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