{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:35:46Z","timestamp":1761824146469,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ventral skull base (VSB) surgery has associated morbidity and mortality that is poorly defined. In this study we aim to identify factors associated with adverse events in VSB surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried the database of the American College of Surgeons National Surgical Quality Improvement Program for cases of VSB surgery during the period 2005\u20102014. Patients with complications, readmissions, reoperations, or mortality were compared to those without adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine hundred patients were included; 253 (28.1%) had complications, underwent reoperation, were readmitted, or died. These patients were older (42.6% vs 32.8, <jats:italic>p<\/jats:italic> = 0.032) and had higher rates of congestive heart failure (CHF) (3.2% vs 0.2%, <jats:italic>p<\/jats:italic> &lt; 0.0001), disseminated cancer (8.3% vs 4.6%, <jats:italic>p<\/jats:italic> = 0.032), and preoperative sepsis (8.7% vs 2.2%, <jats:italic>p<\/jats:italic> &lt; 0.0001). Other comorbidities included long\u2010term steroid use (13.4% vs 9.0%, <jats:italic>p<\/jats:italic> = 0.046) and higher rates of preoperative transfusion (2.4% vs 0%, <jats:italic>p<\/jats:italic> &lt; 0.0001). The most common complication was bleeding (13.7%). Preoperative systemic sepsis (odds ratio [OR], 2.6; 95% confidence interval [CI], 1.0\u20106.6) and lower hematocrit (OR, 2.1; 95% CI, 1.4\u20103.4) were more likely to be associated with a complication. Those with disseminated cancer (OR, 12.0; 95% CI, 2.9\u201050.5) were more likely to experience 30\u2010day mortality. Black patients had lower rates of reoperation (OR, 0.3; 95% CI, 0.1\u20100.8), whereas patients with CHF (OR, 12.6; 95% CI, 1.7\u201094.4) and hypertension (OR, 2.1; 95% CI, 1.1\u20104.0) had higher rates of reoperation. Predictors of extended length of stay were Hispanic ethnicity (OR, 2.2; 95% CI, 1.2\u20104.1) and lower hematocrit (OR, 2.3; 95% CI, 1.5\u20103.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VSB surgery can involve significant morbidity and mortality, and thus identifying risk factors allows for better prognostication and delivery of care in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22433","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T20:43:45Z","timestamp":1572554625000},"page":"1485-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Morbidity and mortality associated with ventral skull base surgery: analysis of the National Surgical Quality Improvement Program"],"prefix":"10.1002","volume":"9","author":[{"given":"Roshansa","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana H.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica C.","family":"Azmy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirali M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordon G.","family":"Grube","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne D.","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-7818","authenticated-orcid":false,"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark NJ"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Department of Ophthalmology and Visual Science Rutgers New Jersey Medical School  Newark 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