{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:44:44Z","timestamp":1790729084219,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature and Science Foundation of China","doi-asserted-by":"crossref","award":["81870706"],"award-info":[{"award-number":["81870706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature and Science Foundation of China","doi-asserted-by":"crossref","award":["31570932"],"award-info":[{"award-number":["31570932"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature and Science Foundation of China","doi-asserted-by":"crossref","award":["81700888"],"award-info":[{"award-number":["81700888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature and Science Foundation of China","doi-asserted-by":"crossref","award":["81701589"],"award-info":[{"award-number":["81701589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature and Science Foundation of China","doi-asserted-by":"crossref","award":["81670914"],"award-info":[{"award-number":["81670914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature and Science Foundation of China","doi-asserted-by":"crossref","award":["81870707"],"award-info":[{"award-number":["81870707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature and Science Foundation of China","doi-asserted-by":"crossref","award":["81970865"],"award-info":[{"award-number":["81970865"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Research and Development Projects of Shanxi Province","award":["201703D321008"],"award-info":[{"award-number":["201703D321008"]}]},{"name":"Shenzhen Science, Technology and Innovation Committee","award":["JCYJ20170307162827158"],"award-info":[{"award-number":["JCYJ20170307162827158"]}]},{"name":"Shenzhen Science, Technology and Innovation Committee","award":["KQTD20170331145453160"],"award-info":[{"award-number":["KQTD20170331145453160"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The therapeutic efficacy of allergic rhinitis (AR) needs to be improved. Probiotics have immunoregulatory functions. In this study we evaluated the effects of protein extracts of probiotics in the amelioration of AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Extracts of <jats:italic>Bifidobacterium infantis<\/jats:italic> (EBI) were prepared by lysing the live probiotics. AR mice were developed to be used to evaluate the therapeutic efficacy of EBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results show that EBI induced interleukin (IL)\u201010\u2012producing dendritic cells (DCs) via increasing IL\u201035 and signal transducer and activator of transcription 3 (STAT3) phosphorylation. IL\u201010\u2012expressing DCs induced IL\u201010\u2012producing B cells (B10 cells), with the latter showing immunosuppressive functions. After challenge with specific antigens, AR mice showed sneezing, nasal itch, and increases in serum\u2010specific immunoglobulin E (IgE) and mouse mast cell protease\u20101; higher levels of T helper 2 (Th2) cytokines (IL\u20104, 67.17 \u00b1 10.66; IL\u20105, 62.83 \u00b1 9.70; IL\u201013, 51.00 \u00b1 6.69, before treatment) in nasal mucosal protein extracts, which were significantly suppressed (IL\u20104, 27.00 \u00b1 6.66; IL\u20105, 23.86 \u00b1 4.53; IL\u201013, 25.67 \u00b1 4.93, after treatment (<jats:italic>p<\/jats:italic> &lt; 0.001) by administration with EBI nasal drops.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EBI can suppress AR via inducing B10 cells. Thus, after carrying out required preclinical experiments and tests, EBI has the translational potential to be used in the treatment of AR and other allergic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22438","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T21:44:27Z","timestamp":1571348667000},"page":"1289-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Probiotic extracts ameliorate nasal allergy by inducing interleukin\u201035\u2012producing dendritic cells in mice"],"prefix":"10.1002","volume":"9","author":[{"given":"Jin\u2010Mei","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Second Hospital Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"Research Center of Allergy &amp; Immunology Shenzhen University School of Medicine  Shenzhen China"},{"name":"Department of Otolaryngology, Head &amp; Neck Surgery First Affiliated Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Fang","family":"An","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Second Hospital Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Min","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Second Hospital Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Rui","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Second Hospital Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Nan","family":"Song","sequence":"additional","affiliation":[{"name":"Research Center of Allergy &amp; Immunology Shenzhen University School of Medicine  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Hua","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shenzhen Hospital, Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Qian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shenzhen Hospital, Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head &amp; Neck Surgery First Affiliated Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u2010Bo","family":"liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shenzhen Hospital, Southern Medical University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Qing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery Second Hospital Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3650-0416","authenticated-orcid":false,"given":"Ping\u2010Chang","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Center of Allergy &amp; Immunology Shenzhen University School of Medicine  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12874"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21385"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2014.35.3794"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1091005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.12.004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12780"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0391-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12555"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2015.02.001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12324"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5104-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480415"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493298"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2018.10.009"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2017.63.10.18"},{"key":"e_1_2_5_17_1","first-page":"253","article-title":"Role of probiotics in health and disease: a review","volume":"63","author":"Singh VP","year":"2013","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2017.04.011"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10946"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00507"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04322-3"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.12.011"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.041"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00098"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646710"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elt028"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-77572016-0277"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.719955"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S104508"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21492"},{"key":"e_1_2_5_31_1","first-page":"5256","article-title":"Probiotics enhance the effect of allergy immunotherapy on regulating antigen specific B cell activity in asthma patients","volume":"8","author":"Liu J","year":"2016","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.08.051"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.04.008"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22438","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:50:19Z","timestamp":1694242219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,17]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/alr.22438"],"URL":"https:\/\/doi.org\/10.1002\/alr.22438","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,17]]},"assertion":[{"value":"2019-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}