{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:22:42Z","timestamp":1747146162675,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR002490"],"award-info":[{"award-number":["KL2TR002490"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["DK065988"],"award-info":[{"award-number":["DK065988"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BOUCHE15R0"],"award-info":[{"award-number":["BOUCHE15R0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Topical mometasone is frequently used as an intranasal spray, on drug\u2010eluting stents, and compounded by specialty pharmacies as a sinus rinse. A typical sinus rinse contains 1.2 mg of mometasone dissolved in 240 mL of buffered saline and is flushed through the sinonasal cavity. The mometasone irrigation rapidly flows to the contralateral sinonasal cavity or the nasopharynx with a contact time on the order of 5 to 10 seconds. However, no information is available on the absorption rate of topical mometasone on the sinonasal surface.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To determine the absorption characteristics of mometasone, we harvested nasal epithelium from 2 healthy donors and differentiated them into a mature ciliated epithelium on Millicell membranes. We applied mometasone to the apical surface for various time intervals and then rinsed off non\u2010absorbed mometasone with phosphate\u2010buffered saline. Millicell membranes with the adherent epithelial cells were then harvested and stored in guanidine hydrochloride for quantification using high\u2010performance liquid chromatography\u2013mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty percent of the maximal absorption occurred after an average of 38 minutes after application, and maximal absorption occurred after an average of 114 minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data provide an estimate for rates of absorption of mometasone applied to the sinonasal cavity and suggest that the absorption rates poorly match contact time during saline lavage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22441","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T14:43:10Z","timestamp":1571668990000},"page":"1451-1455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mometasone absorption in cultured airway epithelium"],"prefix":"10.1002","volume":"9","author":[{"given":"Tuong T.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Marsico Lung Institute University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Mascenik","sequence":"additional","affiliation":[{"name":"Marsico Lung Institute University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Marsico Lung Institute University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhianna E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Marsico Lung Institute University of North Carolina at Chapel Hill  Chapel Hill NC"},{"name":"Department of Cell Biology and Physiology University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian D.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M.","family":"Zanation","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Charles S.","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent A.","family":"Senior","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott H.","family":"Randell","sequence":"additional","affiliation":[{"name":"Marsico Lung Institute University of North Carolina at Chapel Hill  Chapel Hill NC"},{"name":"Department of Cell Biology and Physiology University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandie M.","family":"Ehrmann","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1670-8401","authenticated-orcid":false,"given":"Adam J.","family":"Kimple","sequence":"additional","affiliation":[{"name":"Marsico Lung Institute University of North Carolina at Chapel Hill  Chapel Hill NC"},{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill NC"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill  Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.037"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21588"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.04.038"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23773"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2016.1220833"},{"key":"e_1_2_6_9_1","first-page":"CD011991","article-title":"Short\u2010course oral steroids alone for chronic rhinosinusitis","volume":"4","author":"Head K","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000421"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22324"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21047"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21724"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21189"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22093"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2008.01.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40248-016-0054-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80113-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0276MA"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.174"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-125-7_8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1934-z"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22441","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T12:48:07Z","timestamp":1694177287000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,21]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/alr.22441"],"URL":"https:\/\/doi.org\/10.1002\/alr.22441","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"type":"print","value":"2042-6976"},{"type":"electronic","value":"2042-6984"}],"subject":[],"published":{"date-parts":[[2019,10,21]]},"assertion":[{"value":"2019-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}