{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:35:21Z","timestamp":1780590921035,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["T32GM008620"],"award-info":[{"award-number":["T32GM008620"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["TL1TR001415\u201004"],"award-info":[{"award-number":["TL1TR001415\u201004"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, there has been mounting evidence suggesting the efficacy of steroid\u2010eluting stents (SES) for management of chronic rhinosinusitis after endoscopic sinus surgery (ESS). This meta\u2010analysis serves to evaluate the efficacy of SES in improving postoperative outcomes after ESS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature search was performed of PubMed for articles published between 1985 and 2018. The outcome variables were reported at, on average, 30 days postintervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven of the 76 published studies, all of which were industry\u2010sponsored, were included for a collective cohort of 444 SES and 444 control sinuses. In patients who received SES vs controls, collective odds ratios (ORs) for postoperative need for intervention, surgery, and oral steroid were 0.45 (95% confidence interval [CI], 0.33\u20100.62; <jats:italic>p<\/jats:italic> &lt; 0.001), 0.30 (95% CI, 0.18\u20100.52; <jats:italic>p<\/jats:italic> &lt; 0.001), and 0.58 (95% CI, 0.40\u20100.84; <jats:italic>p<\/jats:italic> = 0.004), respectively. In addition, collective ORs for frontal sinus ostia (FSO) patency, moderate\u2010to\u2010severe adhesion\/scarring, and increase in polyp score were 2.53 (95% CI, 1.61\u20103.97; <jats:italic>p<\/jats:italic> &lt; 0.001), 0.28 (95% CI, 0.13\u20100.59; <jats:italic>p<\/jats:italic> &lt; 0.001), and 0.42 (95% CI, 0.25\u20100.74; <jats:italic>p<\/jats:italic> = 0.002), respectively. Collective mean differences for FSO\/ethmoid inflammation and FSO diameter were \u221210.86 mm (<jats:italic>p<\/jats:italic> &lt; 0.001) and +1.34 mm (<jats:italic>p<\/jats:italic> &lt; 0.001), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aggregate evidence suggests that SES can improve ESS outcomes by reducing rates of postoperative intervention and recurrent polyposis and inflammation, while promoting FSO patency. All included and analyzed studies were industry\u2010sponsored and ruling\u2010out publication bias was not possible. Future independent and nonsponsored studies to further evaluate SES's long\u2010term efficacy are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22443","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T16:19:47Z","timestamp":1568996387000},"page":"1443-1450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Efficacy of steroid\u2010eluting stents in management of chronic rhinosinusitis after endoscopic sinus surgery: updated meta\u2010analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Khodayar","family":"Goshtasbi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Abouzari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Abiri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Yasaka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Sahyouni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bitner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby A.","family":"Tajudeen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rush University Medical Center  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0718","authenticated-orcid":false,"given":"Edward C.","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Summary health statistics for U.S. adults: National Health Interview Survey, 2006","volume":"235","author":"Pleis JR","year":"2007","journal-title":"Vital Health Stat 10"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2013.34.3675"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70152-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.129815"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21425"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.12.53"},{"key":"e_1_2_6_9_1","first-page":"75","article-title":"Mometasone implant for chronic rhinosinusitis","volume":"5","author":"Wei CC","year":"2012","journal-title":"Med Devices (Auckl)"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000012"},{"key":"e_1_2_6_11_1","first-page":"CD010436","article-title":"Steroid\u2010eluting sinus stents for improving symptoms in chronic rhinosinusitis patients undergoing functional endoscopic sinus surgery","volume":"6","author":"Huang Z","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20072"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2017.1281740"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21044"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21963"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.5604\/00306657.1199343"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin16.070"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811435968"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26140"},{"key":"e_1_2_6_21_1","first-page":"28","article-title":"Safety and effectiveness of a bioabsorbable steroid\u2010releasing implant for the paranasal sinus ostia: a randomized clinical trial","volume":"144","author":"Luong A","year":"2018","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22238"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21741"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20020"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21015"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-30"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3221"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin15.079"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino09.178"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818773065"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06891-X"},{"key":"e_1_2_6_32_1","first-page":"MR000033","article-title":"Industry sponsorship and research outcome","volume":"2","author":"Lundh A","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02605-2"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22443","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/alr.22443","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T12:48:38Z","timestamp":1694177318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/alr.22443"],"URL":"https:\/\/doi.org\/10.1002\/alr.22443","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"2019-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}