{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:21:29Z","timestamp":1788200489357,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sinusitis and rhinitis are common diseases for which patients seek medical attention. Alternative therapies constitute a multibillion\u2010dollar industry despite poorly established efficacy and safety profiles. This study was designed to identify and grade the evidence for alternative therapies purported to treat sinusitis and rhinitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A modified Delphi method was used to establish a consensus opinion among rhinology experts of the current evidence for efficacy, potential harm, and future research needs for alternative therapies in sinusitis and rhinitis. Following the initial Delphi round of discussion, a Google search query was performed to identify topics and review online reports of benefit. Subsequent rounds established search criteria and inclusion\/exclusion criteria for a systematic literature review utilizing PubMed, EMBASE, and Cochrane databases. Centre for Evidence\u2010Based Medicine (CEBM) and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) criteria were used to assess levels of evidence and recommendations. Final Delphi rounds were performed until consensus opinions could be reached.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over 60 potential alternative therapies for sinusitis and rhinitis were identified. The literature review included 2066 titles with 220 full\u2010text articles found to be relevant. Most of the therapies had little to no scientific evidence; however, acupuncture, capsaicin, bromelain, and butterbur extract currently have low to moderate\u2010high GRADE rating. Allergic rhinitis was the most common disease studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Some alternative therapies show promise as potential treatments for sinusitis and rhinitis, mostly compared to placebo. Comparisons to traditional therapies are lacking. For other alternative therapies, many websites included unsubstantiated claims of benefit and ignored potential side effects for which patients should be warned appropriately.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22488","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T06:22:52Z","timestamp":1582784572000},"page":"496-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-6355","authenticated-orcid":false,"given":"Arthur W.","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery Cedars\u2010Sinai Medical Center  Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Gettelfinger","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Indiana University School of Medicine  Indianapolis IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Y.","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Indiana University School of Medicine  Indianapolis IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Mort","sequence":"additional","affiliation":[{"name":"Bellarmine University  Louisville KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Rhinology, Sinus and Skull Base Kentuckiana Ear, Nose, &amp; Throat  Louisville KY"},{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery University of Louisville  Louisville KY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4297"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.10.014"},{"key":"e_1_2_6_4_1","article-title":"Weighing alternative remedies","author":"American Medical Association","year":"2012","journal-title":"American Medical News"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328329226f"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2012.02.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3264"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.5.1461"},{"key":"e_1_2_6_9_1","first-page":"720879","article-title":"Factors associated with the use of different treatment modalities among patients with upper airway diseases in Taiwan: a cross\u2010sectional survey study","volume":"2013","author":"Koo M","year":"2013","journal-title":"J Allergy (Cairo)"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21446"},{"key":"e_1_2_6_11_1","first-page":"586","article-title":"Use of complementary and alternative medical therapies for chronic rhinosinusitis: a Canadian perspective","volume":"39","author":"Rotenberg BW","year":"2010","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_12_1","first-page":"517","article-title":"Use of alternative medicine in Israeli chronic rhinosinusitis patients","volume":"38","author":"Yakirevitch A","year":"2009","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_13_1","unstructured":"Office of Dietary Supplements.Multivitamin\/mineral Supplements: Fact Sheet for Health Professionals.https:\/\/ods.od.nih.gov\/factsheets\/MVMS-HealthProfessional\/. 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