{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:52:46Z","timestamp":1778255566482,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In this study we aim to describe presenting characteristics and identify prognostic factors for disease resolution in patients with chronic rhinosinusitis (CRS) in the setting of eosinophilic granulomatosis with polyangiitis (EGPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients evaluated at a tertiary care center with diagnoses of EGPA and CRS were identified. Descriptive statistics were obtained. Univariate analysis was used to search for prognostic factors associated with higher Lund\u2010Mackay score at presentation and disease resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four patients were included with a mean age of 52.7 (standard deviation, 14) years. Twenty\u2010one patients (47.7%) were female, all had a diagnosis of asthma, and 36 (83.7%) had eosinophils &gt;10%. Common presenting symptoms for CRS included nasal discharge (87.9%) followed by nasal congestion (83.9%) and facial pain and pressure (83.8%). Medical management of CRS included systemic corticosteroids (93.2%) and systemic antibiotics (75%). Surgical intervention occurred in 29 patients (67%). Nine patients (20.5%) had resolution of sinus symptoms, including 4 with imaging confirmation. Fourteen patients (31.8%) had continued CRS, but with improved symptoms, whereas 9 patients (20.5%) had continued CRS with no improvement in symptoms. Eleven patients (25%) were lost to follow\u2010up and 4 (9.1%) died. Univariate analysis did not show antineutrophil cytoplasmic antibody positivity, presence of peripheral eosinophilia, gender, age, or absence of systemic therapy to be predictive of higher Lund\u2010Mackay score at presentation or predictive of disease resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRS in patients with EGPA is often refractory to medical and surgical management. Treatment of these patients should occur in a multidisciplinary setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22503","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T04:30:30Z","timestamp":1575347430000},"page":"217-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Chronic rhinosinusitis in eosinophilic granulomatosis with polyangiitis: clinical presentation and antineutrophil cytoplasmic antibodies"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-0751","authenticated-orcid":false,"given":"Christopher M.","family":"Low","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina A.","family":"Keogh","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias S.","family":"Saba","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson R.","family":"Gruszczynski","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvise","family":"Berti","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Mayo Clinic  Rochester MN"},{"name":"Department of Rheumatology Santa Chiara Hospital  Trento Italy"},{"name":"Centre for Integrative Biology University of Trento  Trento Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Specks","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misbah","family":"Baqir","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron M","family":"Smith","sequence":"additional","affiliation":[{"name":"Biomedical Statistics and Informatics Mayo Clinic  Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3745-2727","authenticated-orcid":false,"given":"Garret","family":"Choby","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2012Head and Neck Surgery Mayo Clinic  Rochester 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