{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:44:49Z","timestamp":1790649889841,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic chronic rhinosinusitis (eCRS) is an inflammatory endotype of CRS. Contemporary treatment includes creation of a \u201cneo\u2010sinus\u201d cavity and postoperative corticosteroid irrigations. Not all patients gain control with local therapy. This study aims to determine, in patients with polyp recurrence, the most common sinuses involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective case\u2010series was conducted on consecutive adult (\u226518 years) post\u2010FESS eCRS patients followed for a minimum of 12 months. All patients had a neo\u2010sinus cavity created surgically and used corticosteroid irrigations daily for 3\u20106 months, then tapered to disease control. Sinus cavities were assessed by endoscopy on last follow\u2010up. Polyp recurrence was defined as a score of 5 or 6 in the MLMES in \u22653 sinus cavities. Patient\u2010reported outcomes based on SNOT22 and NSS, frequency of corticosteroid irrigations, and courses of systemic antibiotics and corticosteroid were collected. The pattern of sinus involvement was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      A total of 342 sinus cavities were assessed (mean \u00b1 standard deviation, 54.9 \u00b1 13.4 years, 43.2% female). Polyp recurrence occurred in 4.3% (6.4% of patients, n = 7 unilateral) of sinus cavities. Frontal and ethmoid sinus cavities were most affected in those with polyp recurrence, compared to the maxilla and sphenoid (100% vs 100% vs 53% vs 53%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). Although those patients with polyp recurrence utilized more systemic corticosteroids courses per year (0.4 \u00b1 0.4 vs 0.1 \u00b1 0.3,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), the use of corticosteroid irrigations was similar (% &gt;4\/week; 66.7% vs 48.9%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.13). Prior surgery was more common in patients with polyp recurrence (86.7% vs 53.5%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The frontal and ethmoid sinuses were most affected in those patients with polyp recurrence. Whether the disease is more active in this location or topical therapy has limited access requires further evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22529","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T09:12:15Z","timestamp":1582881135000},"page":"604-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Topography of polyp recurrence in eosinophilic chronic rhinosinusitis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-8005","authenticated-orcid":false,"given":"Jessica W.","family":"Grayson","sequence":"first","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Li","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-8684","authenticated-orcid":false,"given":"Jacqueline","family":"Ho","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"},{"name":"St Vincent's Clinical School, Faculty of Medicine University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7250-2200","authenticated-orcid":false,"given":"Raquel","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Rimmer","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"},{"name":"Woolcock Institute University of Sydney  Sydney Australia"},{"name":"Faculty of Medicine Notre Dame University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Sewell","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School, Faculty of Medicine University of New South Wales  Sydney Australia"},{"name":"Immunology Division Garvan Institute of Medical Research  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-8975","authenticated-orcid":false,"given":"Richard J.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research University of New South Wales  Sydney Australia"},{"name":"Faculty of Medicine and Health Sciences Macquarie University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"issue":"3","key":"e_1_2_6_2_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.01.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000124938.46948.c7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21032"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21686"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22371"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22093"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22331"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21047"},{"key":"e_1_2_6_12_1","article-title":"Eosinophilic chronic rhinosinusitis (eCRS) managed by creation of functional neo\u2010sinus cavity and post\u2010operative corticosteroid irrigation care","author":"Li W","journal-title":"Int Forum Allergy Rhinol"},{"key":"e_1_2_6_13_1","unstructured":"HoJ LiW GraysonJW et\u00a0al.Systemic medication use in post\u2010surgical patients with eosinophilic chronic rhinosinusitis (eCRS). 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