{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:39:19Z","timestamp":1791689959653,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Healthy Humming, LLC"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic nasal congestion affects 20% of the population with significant impact on quality of life. This study investigated the simultaneous administration of nasal acoustic vibration and oscillating expiratory pressure for the treatment of nasal congestion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with chronic nasal congestion but without fixed anatomic obstruction participated in a prospective clinical study applying simultaneous acoustic vibrations and positive expiratory pressure to the nasal cavity twice daily over 5 weeks. Safety was assessed by rhinoscopy and patient questionnaires. Efficacy was assessed using peak nasal inspiratory flow (PNIF), visual analogue scale (VAS) of nasal symptoms, Total Nasal Symptom Score (TNSS), Nasal Obstruction and Septoplasty Effectiveness (NOSE) score, and the 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients (mean age 39 years, 65% female) completed the study with no adverse effects. At the 2 week follow\u2010up, PNIF improved by 25.0 L\/min (31% increase from baseline, <jats:italic>p<\/jats:italic> &lt; 0.001). At the 5 week follow\u2010up, nasal congestion VAS improved from mean \u00b1 SD of 5.8 \u00b1 2.4 to 2.6 \u00b1 2.3, TNSS improved from 7.2 \u00b1 3.5 to 3.5 \u00b1 3.1, NOSE improved from 50.4 \u00b1 19.9 to 23.3 \u00b1 17.2, and SNOT\u201022 improved from 31.7 \u00b1 20.3 to 14.2 \u00b1 12.7, all <jats:italic>p<\/jats:italic> &lt; 0.001. Eighty percent of patients would use the device again and 87.5% would recommend to others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Simultaneous administration of acoustic vibration and oscillating expiratory pressure appears to be a safe treatment for chronic nasal congestion. Results from this initial study are promising with regard to efficacy but will require further study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22537","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T10:55:01Z","timestamp":1582800901000},"page":"610-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A novel device combining acoustic vibration with oscillating expiratory pressure for the treatment of nasal congestion"],"prefix":"10.1002","volume":"10","author":[{"given":"Zachary M.","family":"Soler","sequence":"first","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Salvador","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lackland","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent M.","family":"Desiato","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Storck","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology \u2010 Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S8077"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3603"},{"key":"e_1_2_6_4_1","first-page":"CD011699","article-title":"Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis","volume":"9","author":"Lee AL","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"e_1_2_6_5_1","first-page":"CD003147","article-title":"Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis","volume":"2019","author":"McIlwaine M","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.13.11"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin13.126"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.02.006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.09.016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz070"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12778"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin13.181"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:44:21Z","timestamp":1694004261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,27]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/alr.22537"],"URL":"https:\/\/doi.org\/10.1002\/alr.22537","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,27]]},"assertion":[{"value":"2019-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}