{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:48:00Z","timestamp":1784990880160,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Both the prevalence of sinonasal inverted papilloma (IP) and the causal association with alpha\u2010human papillomaviruses (alpha\u2010HPVs) are controversial. In this study we aimed to determine HPV status in histologically selected, microdissected, formalin\u2010fixed, and paraffin\u2010embedded tissue samples of IP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HPV status was assessed retrospectively by polymerase chain reaction (PCR)\u2010bead\u2012based multiplex genotyping on tissue samples of patients diagnosed with IP and consecutively treated with endoscopic resection. Forty\u2010one HPV genotypes were considered, distinguishing between high risk and low risk. HPV status was correlated with demographics and clinical variables. Sixty sinonasal IP tissue samples were initially considered. After exclusion of 5 cases due to insufficient quality\/quantity of the samples, 55 patients were included for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HPV\u2010DNA sequences were identified in 34 of 55 (61.8%) IPs, with a higher prevalence of high\u2010risk than low\u2010risk HPV genotypes (19 [55.9%] and 15 cases [44.1%], respectively). HPV16 strongly prevailed among the high\u2010risk HPV cases (84.2%), and HPV54 prevailed among the low\u2010risk HPV cases (53.3%). IPs with origin within the maxillary sinus were significantly associated with high\u2010risk HPV (<jats:italic>p<\/jats:italic> = 0.019). No significant associations emerged between HPV status and demographics or clinical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a series of 55 IP tissue samples, HPV\u2010DNA sequences were identified in 61.8% of cases, which differs from the data of previous investigations. Further case\u2010control studies are advocated to confirm this prevalence in the Italian population addressed, and also to clarify any pathogenic involvement of HPV in the natural history of IPs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22539","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T11:14:25Z","timestamp":1582802065000},"page":"629-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High prevalence of human papillomavirus infection in sinonasal inverted papilloma: a single\u2010institution cohort of patients"],"prefix":"10.1002","volume":"10","author":[{"given":"Giuliana","family":"Frasson","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Cesaro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgical Pathology and Cytopathology Section University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Cazzador","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section University of Padova  Padova Italy"},{"name":"Department of Neuroscience, Section of Human Anatomy University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Traverso","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgical Pathology and Cytopathology Section University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Emanuelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Borsetto","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Munari","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgical Pathology and Cytopathology Section University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Salmaso","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgical Pathology and Cytopathology Section University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Boscolo\u2010Rizzo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgical Pathology and Cytopathology Section University of Padova  Padova Italy"},{"name":"Veneto Cancer Registry\u2012Veneto Regional Authority  Venezia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"El\u2010NaggarA ChanJKC GrandisJR et\u00a0al.WHO classification of head and neck tumours 4th ed. IARC;2017.http:\/\/publications.iarc.fr\/book-and-report-series\/who-iarc-classification-of-tumours\/who-classification-of-head-and-neck-tumours-2017."},{"key":"e_1_2_6_3_1","unstructured":"BarnesL EvesonJW ReichartP SidranskyD.Pathology and genetics of head and neck tumours 3rd ed. IARC;2005.http:\/\/publications.iarc.fr\/book-and-report-series\/who-iarc-classification-of-tumours\/pathology-and-genetics-of-head-and-neck-tumours-2005."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2016.03.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2016.11.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23688"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v7072802"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4750"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv403"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.12.020"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199209000-00003"},{"key":"e_1_2_6_12_1","first-page":"406","article-title":"Prevalence of human papillomavirus in sinonasal papillomas: a study using polymerase chain reaction and in situ hybridization","volume":"5","author":"McLachlin CM","year":"1992","journal-title":"Mod Pathol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131008901002"},{"key":"e_1_2_6_14_1","first-page":"113S","article-title":"Significance of human papillomaviruses (HPV) in sinonasal papillomas","volume":"116","author":"Kraft M","year":"2000","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1139-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21358"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.3985"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4549-0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.9807"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3204-7_2"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-008-0048-3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21772"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016480802620647"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.04.001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21524"},{"key":"e_1_2_6_26_1","first-page":"785","article-title":"Possible synergistic interactions among multiple HPV genotypes in women suffering from genital neoplasia","volume":"19","author":"Hajia M","year":"2018","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21789"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30238"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989570144-3"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit577"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.5.3186"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21996"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21215"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx736"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31971"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22539","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:44:26Z","timestamp":1694004266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,27]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/alr.22539"],"URL":"https:\/\/doi.org\/10.1002\/alr.22539","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,27]]},"assertion":[{"value":"2019-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}