{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:57:48Z","timestamp":1779220668397,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The technique for transnasal endoscopic resection of inverted papilloma (IP) has evolved considerably during the last 20 years. The aim of the present study is to retrospectively analyze a single tertiary center series, with special emphasis on assessing the value of an \u201cinsertion\u2010driven\u201d technique on local control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing endoscopic resection for IP at the University of Brescia during the period 1991 to 2015 were enrolled. Site of origin and extension of IPs were assessed, together with presence of dysplasia and carcinoma in situ. Patients were divided in 3 cohorts: (1) historical cohort (treated before 2008), (2) contemporary \u201ccentripetal\u201d cohort (treated with a traditional technique after 2008), and (3) contemporary \u201cinsertion\u2010driven\u201d cohort (treated with insertion\u2010driven resection). Groups were compared considering outcomes and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The series included 210 patients. Mean follow\u2010up was 77.8 months. Thirty\u2010eight (18.1%) patients showed precancerous changes. Maxillary involvement (<jats:italic>p<\/jats:italic> = 0.021) and presence of precancerous changes (<jats:italic>p<\/jats:italic> = 0.013) were significantly associated with a higher risk of recurrence. Five\u2010year local control rate before and after 2008 was 95.1% and 90.5%, respectively. The insertion\u2010driven cohort was associated with lower disease control when IPs involved the maxillary sinus. The rate of complications was 11.9%. The insertion\u2010driven cohort was associated with a lower rate of major complications (<jats:italic>p<\/jats:italic> = 0.098).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative evidence of precancerous changes and\/or involvement of maxillary sinus should prompt the surgeon to address the disease more aggressively (centripetal resection). Preoperative imaging and biopsy with abundant material may optimize the chance to stratify patients eligible for less or more conservative approaches.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22541","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T14:26:06Z","timestamp":1582899966000},"page":"619-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["How aggressive should resection of inverted papilloma be? Refinement of surgical planning based on the 25\u2010year experience of a single tertiary center"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-0121","authenticated-orcid":false,"given":"Marco","family":"Ferrari","sequence":"first","affiliation":[{"name":"Unit of Otorhinolaryngology\u2013Head and Neck Surgery University of Brescia  Brescia Italy"},{"name":"Department of Neurosciences Section of Otorhinolaryngology\u2013Head and Neck Surgery, University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2013Head and Neck Surgery University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Mattavelli","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2013Head and Neck Surgery University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Rampinelli","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2013Head and Neck Surgery University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Bertazzoni","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2013Head and Neck Surgery University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Tomasoni","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2013Head and Neck Surgery University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Gualtieri","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2013Head and Neck Surgery University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Nicolai","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Section of Otorhinolaryngology\u2013Head and Neck Surgery, University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0799-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.038"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4571-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21589"},{"key":"e_1_2_6_6_1","first-page":"618","article-title":"Focal hyperostosis on CT of sinonasal inverted papilloma as a predictor of tumor origin","volume":"28","author":"Lee DK","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpradiol.2015.10.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21836"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240401800508"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892418765004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2817-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.116789"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200402000-00003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3243"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2500\/ajra.2014.28.3985","article-title":"Evolution in the treatment of sinonasal inverted papilloma: pedicle\u2010oriented endoscopic surgery","volume":"28","author":"Pagella F","journal-title":"Am J Rhinol Allergy"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-018-0271-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22342"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113793"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.055954"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9195163"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4629-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31971"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200006000-00015"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_6_25_1","first-page":"1","article-title":"European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base","volume":"22","author":"Lund VJ","year":"2010","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.12.094"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22001"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.09.165"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215117000172"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-017-0246-7"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2001.22563"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26659"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3142"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2216-z"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819883298"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2018.32.4504"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4272"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23876"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3616-7"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970401)79:7<1320::AID-CNCR8>3.0.CO;2-K"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0133-2"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1139-1"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23864"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmx108"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23688"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21524"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20115"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10144"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2604-z"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:44:44Z","timestamp":1694004284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/alr.22541"],"URL":"https:\/\/doi.org\/10.1002\/alr.22541","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,28]]},"assertion":[{"value":"2019-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}