{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:13:47Z","timestamp":1783120427948,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Olfactory dysfunction is a common complaint in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose of this article is to critically review all published literature regarding the impact of monoclonal antibodies on CRSwNP\u2010related olfactory dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic literature search was performed in MEDLINE, ScienceDirect, the Cochrane Library electronic databases, and multiple trial registries, followed by extensive hand\u2010searching for the retrieval of relevant studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven trials with a total of 957 patients were eventually identified and systematically reviewed. Six of 7 studies showed that biologic therapy can improve olfactory dysfunction when compared with placebo. Overall, these biologic agents were considered safe and well\u2010tolerated. No cases of olfactory deterioration or olfactory loss were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first meta\u2010analysis presenting clinical outcomes with regard to olfactory function in CRSwNP patients who had been treated with monoclonal antibodies. The positive effect of biologic treatment on the olfactory function of these patients requires further study so that the sustainability of results and duration of treatment can be determined.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.22576","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T15:33:18Z","timestamp":1586187198000},"page":"893-900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of monoclonal antibodies on olfactory dysfunction caused by chronic rhinosinusitis with nasal polyps: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1884-6824","authenticated-orcid":false,"given":"Nikolaos","family":"Tsetsos","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2012Head and Neck Surgery \u201cG. Papanikolaou\u201d General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Markou","sequence":"additional","affiliation":[{"name":"2nd Academic Otorhinolaryngology Department Aristotle University of Thessaloniki, Papageorgiou Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iordanis","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"2nd Academic Otorhinolaryngology Department Aristotle University of Thessaloniki, Papageorgiou Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Summary health statistics for U.S. adults: National Health Interview Survey, 2012","volume":"10","author":"Blackwell DL","year":"2014","journal-title":"Vital Health Stat"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.036"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3286"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3172"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3195"},{"key":"e_1_2_6_9_1","first-page":"47","article-title":"Olfactory mucosa in nasal polyposis: implications for FESS outcome","volume":"48","author":"Konstantinidis I","year":"2010","journal-title":"Rhinology"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600801357"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.5.497"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bju043"},{"key":"e_1_2_6_13_1","first-page":"710","article-title":"Sensory impairments and risk of mortality in older adults","volume":"72","author":"Schubert CR","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin17.156"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin09.144"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31881-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.056"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.047"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.19330"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.044"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21373"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816664879"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318170b5cb"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.22576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alr.22576","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.22576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T13:36:27Z","timestamp":1694007387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.22576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/alr.22576"],"URL":"https:\/\/doi.org\/10.1002\/alr.22576","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,29]]},"assertion":[{"value":"2020-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}