{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:35:54Z","timestamp":1790735754502,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001442"],"award-info":[{"award-number":["UL1TR001442"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapid spread of the severe acute respiratory syndrome\u2010coronavirus\u20102 (SARS\u2010CoV\u20102) and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of coronavirus disease 2019 (COVID\u201019) infection. Two such candidate symptoms include anecdotally reported loss of smell and taste. Understanding the timing and association of smell\/taste loss in COVID\u201019 may help facilitate screening and early isolation of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010institution, cross\u2010sectional study evaluating patient\u2010reported symptoms with a focus on smell and taste was conducted using an internet\u2010based platform on adult subjects who underwent testing for COVID\u201019. Logistic regression was employed to identify symptoms associated with COVID\u201019 positivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1480 patients with influenza\u2010like symptoms underwent COVID\u201019 testing between March 3, 2020, and March 29, 2020. Our study captured 59 of 102 (58%) COVID\u201019\u2013positive patients and 203 of 1378 (15%) COVID\u201019\u2013negative patients. Smell and taste loss were reported in 68% (40\/59) and 71% (42\/59) of COVID\u201019\u2013positive subjects, respectively, compared to 16% (33\/203) and 17% (35\/203) of COVID\u201019\u2013negative patients (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Smell and taste impairment were independently and strongly associated with COVID\u201019 positivity (anosmia: adjusted odds ratio [aOR] 10.9; 95% CI, 5.08\u201023.5; ageusia: aOR 10.2; 95% CI, 4.74\u201022.1), whereas sore throat was associated with COVID\u201019 negativity (aOR 0.23; 95% CI, 0.11\u20100.50). Of patients who reported COVID\u201019\u2013associated loss of smell, 74% (28\/38) reported resolution of anosmia with clinical resolution of illness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In ambulatory individuals with influenza\u2010like symptoms, chemosensory dysfunction was strongly associated with COVID\u201019 infection and should be considered when screening symptoms. Most will recover chemosensory function within weeks, paralleling resolution of other disease\u2010related symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.22579","type":"journal-article","created":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T03:53:22Z","timestamp":1586663602000},"page":"806-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":575,"title":["Association of chemosensory dysfunction and COVID\u201019 in patients presenting with influenza\u2010like symptoms"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1934-4922","authenticated-orcid":false,"given":"Carol H.","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-813X","authenticated-orcid":false,"given":"Farhoud","family":"Faraji","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-0469","authenticated-orcid":false,"given":"Divya P.","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  La Jolla CA"},{"name":"University of California San Diego School of Medicine  La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-8666","authenticated-orcid":false,"given":"Christine E.","family":"Boone","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego Health  La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"DeConde","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2565"},{"key":"e_1_2_6_3_1","article-title":"Coincidence of COVID\u201019 epidemic and olfactory dysfunction outbreak","author":"Bagheri SHR","journal-title":"medRxiv"},{"key":"e_1_2_6_4_1","article-title":"Self\u2010reported olfactory and taste disorders in SARS\u2010CoV\u20102 patients: a cross\u2010sectional study","author":"Giacomelli A","journal-title":"Clin Infect Dis"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000249922.37381.1e"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00122"},{"key":"e_1_2_6_7_1","article-title":"Non\u2010neuronal expression of SARS\u2010CoV\u20102 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID\u201019 patients","author":"Brann D","journal-title":"bioRxiv"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjx025"}],"container-title":["International Forum of Allergy &amp; 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